node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3orf38 | CGGBP1 | ENSP00000322469 | ENSP00000381429 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | 0.628 |
C3orf38 | DNAJB4 | ENSP00000322469 | ENSP00000359799 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | 0.633 |
C3orf38 | MAP10 | ENSP00000322469 | ENSP00000403208 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. | 0.437 |
C3orf38 | NPM3 | ENSP00000322469 | ENSP00000359128 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | Nucleoplasmin-3; Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM ; Belongs to the nucleoplasmin family. | 0.417 |
C3orf38 | STUB1 | ENSP00000322469 | ENSP00000219548 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | E3 ubiquitin-protein ligase CHIP; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Me [...] | 0.420 |
C3orf38 | THOC3 | ENSP00000322469 | ENSP00000265097 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | THO complex subunit 3; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...] | 0.498 |
C3orf38 | ZNF654 | ENSP00000322469 | ENSP00000490842 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.714 |
CGGBP1 | C3orf38 | ENSP00000381429 | ENSP00000322469 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.628 |
CGGBP1 | ZNF654 | ENSP00000381429 | ENSP00000490842 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.670 |
DNAJB4 | C3orf38 | ENSP00000359799 | ENSP00000322469 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.633 |
MAP10 | C3orf38 | ENSP00000403208 | ENSP00000322469 | Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.437 |
NPM3 | C3orf38 | ENSP00000359128 | ENSP00000322469 | Nucleoplasmin-3; Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM ; Belongs to the nucleoplasmin family. | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.417 |
STUB1 | C3orf38 | ENSP00000219548 | ENSP00000322469 | E3 ubiquitin-protein ligase CHIP; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Me [...] | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.420 |
THOC3 | C3orf38 | ENSP00000265097 | ENSP00000322469 | THO complex subunit 3; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...] | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.498 |
ZNF654 | C3orf38 | ENSP00000490842 | ENSP00000322469 | Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Uncharacterized protein C3orf38; May be involved in apoptosis regulation. | 0.714 |
ZNF654 | CGGBP1 | ENSP00000490842 | ENSP00000381429 | Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. | 0.670 |