TMEM40 protein (human) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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[Homology]

Score

TMEM40

Transmembrane protein 40. (233 aa)

Predicted Functional Partners:

SMIM3

0.546

GP1BB

0.507

PPP1R14C

0.502

DNAJC1

0.485

CFTR

0.484

RTL8B

0.441

CDK15

0.426

TMEM62

0.418

TNFAIP8L1

0.417

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK15	TMEM40	ENSP00000406472	ENSP00000322837	Cyclin-dependent kinase 15; Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.	Transmembrane protein 40.	0.426
CFTR	TMEM40	ENSP00000003084	ENSP00000322837	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...]	Transmembrane protein 40.	0.484
DNAJC1	PPP1R14C	ENSP00000366179	ENSP00000355260	DnaJ homolog subfamily C member 1; May modulate protein synthesis.	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.	0.440
DNAJC1	SMIM3	ENSP00000366179	ENSP00000436897	DnaJ homolog subfamily C member 1; May modulate protein synthesis.	Small integral membrane protein 3.	0.488
DNAJC1	TMEM40	ENSP00000366179	ENSP00000322837	DnaJ homolog subfamily C member 1; May modulate protein synthesis.	Transmembrane protein 40.	0.485
DNAJC1	TNFAIP8L1	ENSP00000366179	ENSP00000444215	DnaJ homolog subfamily C member 1; May modulate protein synthesis.	Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family.	0.483
GP1BB	TMEM40	ENSP00000383382	ENSP00000322837	Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.	Transmembrane protein 40.	0.507
PPP1R14C	DNAJC1	ENSP00000355260	ENSP00000366179	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.	DnaJ homolog subfamily C member 1; May modulate protein synthesis.	0.440
PPP1R14C	SMIM3	ENSP00000355260	ENSP00000436897	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.	Small integral membrane protein 3.	0.443
PPP1R14C	TMEM40	ENSP00000355260	ENSP00000322837	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.	Transmembrane protein 40.	0.502
PPP1R14C	TNFAIP8L1	ENSP00000355260	ENSP00000444215	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.	Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family.	0.457
RTL8B	SMIM3	ENSP00000375268	ENSP00000436897	Retrotransposon Gag like 8B; Belongs to the FAM127 family.	Small integral membrane protein 3.	0.485
RTL8B	TMEM40	ENSP00000375268	ENSP00000322837	Retrotransposon Gag like 8B; Belongs to the FAM127 family.	Transmembrane protein 40.	0.441
SMIM3	DNAJC1	ENSP00000436897	ENSP00000366179	Small integral membrane protein 3.	DnaJ homolog subfamily C member 1; May modulate protein synthesis.	0.488
SMIM3	PPP1R14C	ENSP00000436897	ENSP00000355260	Small integral membrane protein 3.	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.	0.443
SMIM3	RTL8B	ENSP00000436897	ENSP00000375268	Small integral membrane protein 3.	Retrotransposon Gag like 8B; Belongs to the FAM127 family.	0.485
SMIM3	TMEM40	ENSP00000436897	ENSP00000322837	Small integral membrane protein 3.	Transmembrane protein 40.	0.546
SMIM3	TNFAIP8L1	ENSP00000436897	ENSP00000444215	Small integral membrane protein 3.	Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family.	0.489
TMEM40	CDK15	ENSP00000322837	ENSP00000406472	Transmembrane protein 40.	Cyclin-dependent kinase 15; Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.	0.426
TMEM40	CFTR	ENSP00000322837	ENSP00000003084	Transmembrane protein 40.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...]	0.484