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GADD45GIP1 protein (human) - STRING interaction network
"GADD45GIP1" - Growth arrest and DNA damage-inducible proteins-interacting protein 1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
GADD45GIP1Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis (222 aa)    
Predicted Functional Partners:
MRPL11
Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family (192 aa)
     
  0.997
MRPL28
Mitochondrial ribosomal protein L28 (256 aa)
     
    0.997
MRPL41
39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
     
  0.996
MRPS30
Mitochondrial ribosomal protein S30 (439 aa)
     
  0.996
MRPL47
Mitochondrial ribosomal protein L47 (250 aa)
     
  0.996
MRPL50
Mitochondrial ribosomal protein L50 (158 aa)
     
    0.996
MRPS34
28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation (225 aa)
     
    0.994
MRPL4
Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family (311 aa)
     
    0.994
MRPL42
Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family (142 aa)
     
    0.994
MRPL40
Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family (206 aa)
     
    0.993
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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