Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MYCBPAPMYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity). (984 aa)    
Predicted Functional Partners:
MYCBP
c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
    
 
 0.986
EPN3
Epsin-3; Epsin 3.
   
 
  0.903
EPN1
Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
   
 
  0.902
ENTHD1
ENTH domain containing 1.
   
 
  0.901
EPN2
Epsin-2; Plays a role in the formation of clathrin-coated invaginations and endocytosis; Belongs to the epsin family.
   
 
  0.901
CLTA
Clathrin light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge.
     
  0.900
CLTB
Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.
     
  0.900
NECAP2
Adaptin ear-binding coat-associated protein 2; Involved in endocytosis.
     
  0.900
CLINT1
Clathrin interactor 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.
     
  0.900
NECAP1
Adaptin ear-binding coat-associated protein 1; Involved in endocytosis.
     
  0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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