| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGT | EDN1 | ENSP00000355627 | ENSP00000368683 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | 0.953 |
| AGT | EDN3 | ENSP00000355627 | ENSP00000337128 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | 0.657 |
| AGT | GALR3 | ENSP00000355627 | ENSP00000249041 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Galanin receptor type 3; Receptor for the hormone galanin. Receptor for the hormone spexin-1. | 0.532 |
| AGT | NTS | ENSP00000355627 | ENSP00000256010 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family. | 0.888 |
| AGT | PMCH | ENSP00000355627 | ENSP00000332225 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Neuropeptide-glutamic acid-isoleucine; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation; Belongs to the melanin-concentrating hormone family. | 0.483 |
| AGT | UTS2 | ENSP00000355627 | ENSP00000054668 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Urotensin-2; Highly potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.737 |
| AGT | UTS2B | ENSP00000355627 | ENSP00000340526 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.419 |
| AGT | UTS2R | ENSP00000355627 | ENSP00000323516 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. | 0.587 |
| COX6A2 | GALR3 | ENSP00000287490 | ENSP00000249041 | Cytochrome c oxidase subunit 6A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] | Galanin receptor type 3; Receptor for the hormone galanin. Receptor for the hormone spexin-1. | 0.502 |
| COX6A2 | UTS2R | ENSP00000287490 | ENSP00000323516 | Cytochrome c oxidase subunit 6A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] | Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. | 0.654 |
| EDN1 | AGT | ENSP00000368683 | ENSP00000355627 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | 0.953 |
| EDN1 | EDN3 | ENSP00000368683 | ENSP00000337128 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | 0.971 |
| EDN1 | NTS | ENSP00000368683 | ENSP00000256010 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family. | 0.406 |
| EDN1 | UTS2 | ENSP00000368683 | ENSP00000054668 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | Urotensin-2; Highly potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.852 |
| EDN1 | UTS2B | ENSP00000368683 | ENSP00000340526 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.428 |
| EDN1 | UTS2R | ENSP00000368683 | ENSP00000323516 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. | 0.770 |
| EDN3 | AGT | ENSP00000337128 | ENSP00000355627 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | 0.657 |
| EDN3 | EDN1 | ENSP00000337128 | ENSP00000368683 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Belongs to the endothelin/sarafotoxin family. | 0.971 |
| EDN3 | UTS2 | ENSP00000337128 | ENSP00000054668 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | Urotensin-2; Highly potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.516 |
| EDN3 | UTS2B | ENSP00000337128 | ENSP00000340526 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.447 |
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