node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC181 | HAPLN3 | ENSP00000356780 | ENSP00000457180 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.699 |
CCDC181 | ST6GALNAC3 | ENSP00000356780 | ENSP00000329214 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | 0.485 |
CCDC181 | ZNF660 | ENSP00000356780 | ENSP00000324605 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.609 |
HAPLN3 | CCDC181 | ENSP00000457180 | ENSP00000356780 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.699 |
HAPLN3 | ST6GALNAC3 | ENSP00000457180 | ENSP00000329214 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | 0.404 |
HAPLN3 | ZNF660 | ENSP00000457180 | ENSP00000324605 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.544 |
ST6GALNAC3 | CCDC181 | ENSP00000329214 | ENSP00000356780 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.485 |
ST6GALNAC3 | HAPLN3 | ENSP00000329214 | ENSP00000457180 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.404 |
ST6GALNAC3 | ZNF660 | ENSP00000329214 | ENSP00000324605 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.580 |
TRIM28 | ZNF660 | ENSP00000253024 | ENSP00000324605 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
ZNF660 | CCDC181 | ENSP00000324605 | ENSP00000356780 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family. | 0.609 |
ZNF660 | HAPLN3 | ENSP00000324605 | ENSP00000457180 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. | 0.544 |
ZNF660 | ST6GALNAC3 | ENSP00000324605 | ENSP00000329214 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). | 0.580 |
ZNF660 | TRIM28 | ENSP00000324605 | ENSP00000253024 | Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.522 |