| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCYAP1 | SERTM1 | ENSP00000462647 | ENSP00000325776 | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). ECO:0000250|UniProtKB:P13589, ; Belongs to the glucagon family. | Serine rich and transmembrane domain containing 1. | 0.443 |
| CACNG4 | KCNB2 | ENSP00000262138 | ENSP00000430846 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | 0.420 |
| CACNG4 | SERTM1 | ENSP00000262138 | ENSP00000325776 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | Serine rich and transmembrane domain containing 1. | 0.481 |
| FAM91A1 | SERTM1 | ENSP00000335082 | ENSP00000325776 | Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. | Serine rich and transmembrane domain containing 1. | 0.482 |
| FAM91A1 | TMEM14A | ENSP00000335082 | ENSP00000211314 | Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | 0.463 |
| FAM91A1 | TMEM164 | ENSP00000335082 | ENSP00000361138 | Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. | Transmembrane protein 164; Belongs to the TMEM164 family. | 0.489 |
| HOOK1 | SERTM1 | ENSP00000360252 | ENSP00000325776 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). | Serine rich and transmembrane domain containing 1. | 0.421 |
| KCNB2 | CACNG4 | ENSP00000430846 | ENSP00000262138 | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | 0.420 |
| KCNB2 | SERTM1 | ENSP00000430846 | ENSP00000325776 | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | Serine rich and transmembrane domain containing 1. | 0.450 |
| SERTM1 | ADCYAP1 | ENSP00000325776 | ENSP00000462647 | Serine rich and transmembrane domain containing 1. | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). ECO:0000250|UniProtKB:P13589, ; Belongs to the glucagon family. | 0.443 |
| SERTM1 | CACNG4 | ENSP00000325776 | ENSP00000262138 | Serine rich and transmembrane domain containing 1. | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | 0.481 |
| SERTM1 | FAM91A1 | ENSP00000325776 | ENSP00000335082 | Serine rich and transmembrane domain containing 1. | Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. | 0.482 |
| SERTM1 | HOOK1 | ENSP00000325776 | ENSP00000360252 | Serine rich and transmembrane domain containing 1. | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). | 0.421 |
| SERTM1 | KCNB2 | ENSP00000325776 | ENSP00000430846 | Serine rich and transmembrane domain containing 1. | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | 0.450 |
| SERTM1 | TMEM14A | ENSP00000325776 | ENSP00000211314 | Serine rich and transmembrane domain containing 1. | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | 0.473 |
| SERTM1 | TMEM164 | ENSP00000325776 | ENSP00000361138 | Serine rich and transmembrane domain containing 1. | Transmembrane protein 164; Belongs to the TMEM164 family. | 0.489 |
| TMEM14A | FAM91A1 | ENSP00000211314 | ENSP00000335082 | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. | 0.463 |
| TMEM14A | SERTM1 | ENSP00000211314 | ENSP00000325776 | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | Serine rich and transmembrane domain containing 1. | 0.473 |
| TMEM14A | TMEM164 | ENSP00000211314 | ENSP00000361138 | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | Transmembrane protein 164; Belongs to the TMEM164 family. | 0.537 |
| TMEM164 | FAM91A1 | ENSP00000361138 | ENSP00000335082 | Transmembrane protein 164; Belongs to the TMEM164 family. | Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. | 0.489 |
