node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTRT3 | LRRC31 | ENSP00000333037 | ENSP00000325978 | Actin related protein T3. | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | 0.525 |
ACTRT3 | LRRC34 | ENSP00000333037 | ENSP00000414635 | Actin related protein T3. | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | 0.700 |
ACTRT3 | LRRIQ4 | ENSP00000333037 | ENSP00000342188 | Actin related protein T3. | Leucine rich repeats and IQ motif containing 4. | 0.744 |
ACTRT3 | MYNN | ENSP00000333037 | ENSP00000326240 | Actin related protein T3. | Myoneurin. | 0.734 |
FBXO28 | MYNN | ENSP00000355827 | ENSP00000326240 | F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. | Myoneurin. | 0.497 |
LRRC31 | ACTRT3 | ENSP00000325978 | ENSP00000333037 | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | Actin related protein T3. | 0.525 |
LRRC31 | LRRC34 | ENSP00000325978 | ENSP00000414635 | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | 0.652 |
LRRC31 | LRRIQ4 | ENSP00000325978 | ENSP00000342188 | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | Leucine rich repeats and IQ motif containing 4. | 0.708 |
LRRC31 | MYNN | ENSP00000325978 | ENSP00000326240 | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | Myoneurin. | 0.584 |
LRRC34 | ACTRT3 | ENSP00000414635 | ENSP00000333037 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | Actin related protein T3. | 0.700 |
LRRC34 | LRRC31 | ENSP00000414635 | ENSP00000325978 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | 0.652 |
LRRC34 | LRRIQ4 | ENSP00000414635 | ENSP00000342188 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | Leucine rich repeats and IQ motif containing 4. | 0.730 |
LRRC34 | MYNN | ENSP00000414635 | ENSP00000326240 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | Myoneurin. | 0.810 |
LRRIQ4 | ACTRT3 | ENSP00000342188 | ENSP00000333037 | Leucine rich repeats and IQ motif containing 4. | Actin related protein T3. | 0.744 |
LRRIQ4 | LRRC31 | ENSP00000342188 | ENSP00000325978 | Leucine rich repeats and IQ motif containing 4. | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31. | 0.708 |
LRRIQ4 | LRRC34 | ENSP00000342188 | ENSP00000414635 | Leucine rich repeats and IQ motif containing 4. | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | 0.730 |
LRRIQ4 | MYNN | ENSP00000342188 | ENSP00000326240 | Leucine rich repeats and IQ motif containing 4. | Myoneurin. | 0.735 |
METTL14 | MYNN | ENSP00000373474 | ENSP00000326240 | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts [...] | Myoneurin. | 0.552 |
METTL14 | RIOK2 | ENSP00000373474 | ENSP00000283109 | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts [...] | Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. | 0.477 |
MYNN | ACTRT3 | ENSP00000326240 | ENSP00000333037 | Myoneurin. | Actin related protein T3. | 0.734 |