| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BEST2 | OPTC | ENSP00000448310 | ENSP00000356191 | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | 0.489 |
| BEST2 | RTBDN | ENSP00000448310 | ENSP00000326253 | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.490 |
| COL6A1 | RTBDN | ENSP00000355180 | ENSP00000326253 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.612 |
| GAS6 | RTBDN | ENSP00000331831 | ENSP00000326253 | Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.620 |
| OPTC | BEST2 | ENSP00000356191 | ENSP00000448310 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.489 |
| OPTC | PRPH2 | ENSP00000356191 | ENSP00000230381 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.774 |
| OPTC | RTBDN | ENSP00000356191 | ENSP00000326253 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.572 |
| PRPH2 | OPTC | ENSP00000230381 | ENSP00000356191 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | 0.774 |
| PRPH2 | RHO | ENSP00000230381 | ENSP00000296271 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | 0.987 |
| PRPH2 | RTBDN | ENSP00000230381 | ENSP00000326253 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.624 |
| RHO | PRPH2 | ENSP00000296271 | ENSP00000230381 | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.987 |
| RHO | RTBDN | ENSP00000296271 | ENSP00000326253 | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.502 |
| RTBDN | BEST2 | ENSP00000326253 | ENSP00000448310 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.490 |
| RTBDN | COL6A1 | ENSP00000326253 | ENSP00000355180 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein. | 0.612 |
| RTBDN | GAS6 | ENSP00000326253 | ENSP00000331831 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. | 0.620 |
| RTBDN | OPTC | ENSP00000326253 | ENSP00000356191 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | 0.572 |
| RTBDN | PRPH2 | ENSP00000326253 | ENSP00000230381 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.624 |
| RTBDN | RHO | ENSP00000326253 | ENSP00000296271 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light- induced isomerization of the chromophore 11-cis-retinal to all-trans- retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | 0.502 |
| RTBDN | TSEN2 | ENSP00000326253 | ENSP00000284995 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.655 |
| RTBDN | TTC19 | ENSP00000326253 | ENSP00000261647 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity. | 0.610 |
