node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEST2 | RTBDN | ENSP00000448310 | ENSP00000326253 | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.493 |
GUCA2B | RTBDN | ENSP00000361662 | ENSP00000326253 | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.464 |
GUCY1A2 | RTBDN | ENSP00000282249 | ENSP00000326253 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.503 |
OPTC | PRPH2 | ENSP00000356191 | ENSP00000230381 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.676 |
OPTC | RTBDN | ENSP00000356191 | ENSP00000326253 | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.574 |
PRPH2 | OPTC | ENSP00000230381 | ENSP00000356191 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | 0.676 |
PRPH2 | RTBDN | ENSP00000230381 | ENSP00000326253 | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.428 |
RTBDN | BEST2 | ENSP00000326253 | ENSP00000448310 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate. | 0.493 |
RTBDN | GUCA2B | ENSP00000326253 | ENSP00000361662 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. | 0.464 |
RTBDN | GUCY1A2 | ENSP00000326253 | ENSP00000282249 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit. | 0.503 |
RTBDN | OPTC | ENSP00000326253 | ENSP00000356191 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). | 0.574 |
RTBDN | PRPH2 | ENSP00000326253 | ENSP00000230381 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family. | 0.428 |
RTBDN | TSEN2 | ENSP00000326253 | ENSP00000284995 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.454 |
RTBDN | TTC19 | ENSP00000326253 | ENSP00000261647 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity. | 0.426 |
RTBDN | TTC9B | ENSP00000326253 | ENSP00000311760 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Tetratricopeptide repeat domain 9B; Belongs to the TTC9 family. | 0.435 |
RTBDN | ZER1 | ENSP00000326253 | ENSP00000291900 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. | 0.425 |
RTBDN | ZNF256 | ENSP00000326253 | ENSP00000282308 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | Zinc finger protein 256; Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.541 |
TSEN2 | RTBDN | ENSP00000284995 | ENSP00000326253 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.454 |
TTC19 | RTBDN | ENSP00000261647 | ENSP00000326253 | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.426 |
TTC9B | RTBDN | ENSP00000311760 | ENSP00000326253 | Tetratricopeptide repeat domain 9B; Belongs to the TTC9 family. | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport. | 0.435 |