EFCAB11 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1B1	EFCAB11	ENSP00000285930	ENSP00000326267	Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...]	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	0.531
CCDC113	CETN1	ENSP00000219299	ENSP00000319052	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	0.453
CCDC113	CETN2	ENSP00000219299	ENSP00000359300	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	0.889
CCDC113	CETN3	ENSP00000219299	ENSP00000428259	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	0.453
CCDC113	EFCAB11	ENSP00000219299	ENSP00000326267	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	0.547
CETN1	CCDC113	ENSP00000319052	ENSP00000219299	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	0.453
CETN1	CETN2	ENSP00000319052	ENSP00000359300	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	0.958
CETN1	CETN3	ENSP00000319052	ENSP00000428259	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	0.916
CETN1	EFCAB11	ENSP00000319052	ENSP00000326267	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	0.824
CETN1	SFI1	ENSP00000319052	ENSP00000383145	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. Belongs to the SFI1 family.	0.950
CETN2	CCDC113	ENSP00000359300	ENSP00000219299	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	0.889
CETN2	CETN1	ENSP00000359300	ENSP00000319052	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	0.958
CETN2	CETN3	ENSP00000359300	ENSP00000428259	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	0.961
CETN2	EFCAB11	ENSP00000359300	ENSP00000326267	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	0.559
CETN2	SFI1	ENSP00000359300	ENSP00000383145	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. Belongs to the SFI1 family.	0.999
CETN3	CCDC113	ENSP00000428259	ENSP00000219299	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.	0.453
CETN3	CETN1	ENSP00000428259	ENSP00000319052	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).	0.916
CETN3	CETN2	ENSP00000428259	ENSP00000359300	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...]	0.961
CETN3	EFCAB11	ENSP00000428259	ENSP00000326267	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.	0.728
CETN3	SFI1	ENSP00000428259	ENSP00000383145	Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.	Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. Belongs to the SFI1 family.	0.989