node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC12 | CDC5L | ENSP00000292314 | ENSP00000360532 | Coiled-coil domain containing 12. | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | 0.981 |
CCDC12 | CRNKL1 | ENSP00000292314 | ENSP00000366557 | Coiled-coil domain containing 12. | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. Belongs to the crooked-neck family. | 0.997 |
CCDC12 | CWF19L1 | ENSP00000292314 | ENSP00000326411 | Coiled-coil domain containing 12. | CWF19-like protein 1; CWF19 like cell cycle control factor 1. | 0.734 |
CCDC12 | CWF19L2 | ENSP00000292314 | ENSP00000282251 | Coiled-coil domain containing 12. | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | 0.820 |
CCDC12 | ISY1 | ENSP00000292314 | ENSP00000273541 | Coiled-coil domain containing 12. | ISY1 splicing factor homolog. | 0.806 |
CCDC12 | PRPF19 | ENSP00000292314 | ENSP00000227524 | Coiled-coil domain containing 12. | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] | 0.989 |
CCDC12 | SYF2 | ENSP00000292314 | ENSP00000236273 | Coiled-coil domain containing 12. | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.940 |
CCDC12 | TFIP11 | ENSP00000292314 | ENSP00000384421 | Coiled-coil domain containing 12. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.689 |
CCDC12 | XAB2 | ENSP00000292314 | ENSP00000351137 | Coiled-coil domain containing 12. | Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Belongs to the crooked-neck family. | 0.773 |
CDC5L | CCDC12 | ENSP00000360532 | ENSP00000292314 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | Coiled-coil domain containing 12. | 0.981 |
CDC5L | CRNKL1 | ENSP00000360532 | ENSP00000366557 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. Belongs to the crooked-neck family. | 0.999 |
CDC5L | CWF19L1 | ENSP00000360532 | ENSP00000326411 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | CWF19-like protein 1; CWF19 like cell cycle control factor 1. | 0.977 |
CDC5L | CWF19L2 | ENSP00000360532 | ENSP00000282251 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family. | 0.992 |
CDC5L | ISY1 | ENSP00000360532 | ENSP00000273541 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | ISY1 splicing factor homolog. | 0.996 |
CDC5L | PRPF19 | ENSP00000360532 | ENSP00000227524 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] | 0.999 |
CDC5L | SYF2 | ENSP00000360532 | ENSP00000236273 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family. | 0.999 |
CDC5L | TFIP11 | ENSP00000360532 | ENSP00000384421 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.881 |
CDC5L | XAB2 | ENSP00000360532 | ENSP00000351137 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Belongs to the crooked-neck family. | 0.999 |
CRNKL1 | CCDC12 | ENSP00000366557 | ENSP00000292314 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. Belongs to the crooked-neck family. | Coiled-coil domain containing 12. | 0.997 |
CRNKL1 | CDC5L | ENSP00000366557 | ENSP00000360532 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. Belongs to the crooked-neck family. | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). | 0.999 |