C14orf28 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C14orf28	C20orf204	ENSP00000326846	ENSP00000489747	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.	0.424
C14orf28	CXorf40B	ENSP00000326846	ENSP00000359434	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	Protein CXorf40B.	0.431
C14orf28	DOCK10	ENSP00000326846	ENSP00000493664	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. Belongs to the DOCK family.	0.492
C14orf28	KLHL28	ENSP00000326846	ENSP00000347193	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	Kelch-like protein 28; Kelch like family member 28.	0.564
C14orf28	TOGARAM1	ENSP00000326846	ENSP00000354917	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family.	0.400
C20orf204	C14orf28	ENSP00000489747	ENSP00000326846	Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	0.424
C20orf204	CXorf40B	ENSP00000489747	ENSP00000359434	Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.	Protein CXorf40B.	0.571
CXorf40B	C14orf28	ENSP00000359434	ENSP00000326846	Protein CXorf40B.	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	0.431
CXorf40B	C20orf204	ENSP00000359434	ENSP00000489747	Protein CXorf40B.	Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.	0.571
DOCK10	C14orf28	ENSP00000493664	ENSP00000326846	Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. Belongs to the DOCK family.	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	0.492
KLHL28	C14orf28	ENSP00000347193	ENSP00000326846	Kelch-like protein 28; Kelch like family member 28.	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	0.564
KLHL28	TOGARAM1	ENSP00000347193	ENSP00000354917	Kelch-like protein 28; Kelch like family member 28.	TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family.	0.455
TOGARAM1	C14orf28	ENSP00000354917	ENSP00000326846	TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family.	Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.	0.400
TOGARAM1	KLHL28	ENSP00000354917	ENSP00000347193	TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family.	Kelch-like protein 28; Kelch like family member 28.	0.455