node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFRP1 | COG6 | ENSP00000483486 | ENSP00000397441 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.744 |
ARFRP1 | COG8 | ENSP00000483486 | ENSP00000497669 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.746 |
ARFRP1 | GOLGA1 | ENSP00000483486 | ENSP00000362656 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. | 0.735 |
ARFRP1 | GOLGA4 | ENSP00000483486 | ENSP00000349305 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Golgin subfamily A member 4; Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking. | 0.731 |
ARFRP1 | RAB6A | ENSP00000483486 | ENSP00000311449 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER ; Belongs to the small GTPase superfamily. Rab family. | 0.735 |
ARFRP1 | RIC1 | ENSP00000483486 | ENSP00000416696 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.720 |
ARFRP1 | STX16 | ENSP00000483486 | ENSP00000360183 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. | 0.695 |
ARFRP1 | SYS1 | ENSP00000483486 | ENSP00000243918 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family. | 0.990 |
ARFRP1 | VPS52 | ENSP00000483486 | ENSP00000409952 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.719 |
ARFRP1 | VPS53 | ENSP00000483486 | ENSP00000401435 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.731 |
COG6 | ARFRP1 | ENSP00000397441 | ENSP00000483486 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | 0.744 |
COG6 | COG8 | ENSP00000397441 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG6 | GOLGA1 | ENSP00000397441 | ENSP00000362656 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. | 0.670 |
COG6 | GOLGA4 | ENSP00000397441 | ENSP00000349305 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Golgin subfamily A member 4; Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking. | 0.601 |
COG6 | RAB6A | ENSP00000397441 | ENSP00000311449 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER ; Belongs to the small GTPase superfamily. Rab family. | 0.849 |
COG6 | RIC1 | ENSP00000397441 | ENSP00000416696 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.694 |
COG6 | STX16 | ENSP00000397441 | ENSP00000360183 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. | 0.860 |
COG6 | SYS1 | ENSP00000397441 | ENSP00000243918 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family. | 0.589 |
COG6 | VPS52 | ENSP00000397441 | ENSP00000409952 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.891 |
COG6 | VPS53 | ENSP00000397441 | ENSP00000401435 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized tr [...] | 0.834 |