STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C16orf54Transmembrane protein C16orf54; Chromosome 16 open reading frame 54. (224 aa)    
Predicted Functional Partners:
ASPHD1
Aspartate beta-hydroxylase domain containing 1.
      
 0.803
QPRT
Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA).
      
 0.714
C16orf92
Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.
      
 0.692
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.
   
  
 0.670
HIRIP3
HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
      
 0.664
TMEM219
Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding.
      
 0.661
IFNA17
Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family.
    
   0.626
SEZ6L2
Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family.
      
 0.609
KCTD13
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). Belongs to the BACURD family.
      
 0.601
YPEL3
Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells.
   
  
 0.600
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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