node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKIP1 | DHRS7C | ENSP00000310459 | ENSP00000327975 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | 0.607 |
DHRS7C | AKIP1 | ENSP00000327975 | ENSP00000310459 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. | 0.607 |
DHRS7C | DNAH8 | ENSP00000327975 | ENSP00000333363 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | 0.497 |
DHRS7C | HSD17B3 | ENSP00000327975 | ENSP00000364412 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Testosterone 17-beta-dehydrogenase 3; Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. | 0.518 |
DHRS7C | HSDL1 | ENSP00000327975 | ENSP00000219439 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Inactive hydroxysteroid dehydrogenase-like protein 1; Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | 0.559 |
DHRS7C | MCRIP1 | ENSP00000327975 | ENSP00000461433 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. | 0.606 |
DHRS7C | PLGLB2 | ENSP00000327975 | ENSP00000352458 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Plasminogen like B2. | 0.497 |
DHRS7C | SAYSD1 | ENSP00000327975 | ENSP00000229903 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | SAYSVFN motif domain containing 1. | 0.648 |
DHRS7C | STAM | ENSP00000327975 | ENSP00000366746 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Signal transducing adapter molecule 1; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. | 0.513 |
DHRS7C | STAM2 | ENSP00000327975 | ENSP00000263904 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking process [...] | 0.513 |
DHRS7C | TRDN | ENSP00000327975 | ENSP00000333984 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | 0.473 |
DNAH8 | DHRS7C | ENSP00000333363 | ENSP00000327975 | Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | 0.497 |
DNAH8 | MCRIP1 | ENSP00000333363 | ENSP00000461433 | Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. | 0.472 |
DNAH8 | SAYSD1 | ENSP00000333363 | ENSP00000229903 | Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | SAYSVFN motif domain containing 1. | 0.648 |
HSD17B3 | DHRS7C | ENSP00000364412 | ENSP00000327975 | Testosterone 17-beta-dehydrogenase 3; Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | 0.518 |
HSDL1 | DHRS7C | ENSP00000219439 | ENSP00000327975 | Inactive hydroxysteroid dehydrogenase-like protein 1; Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | 0.559 |
MCRIP1 | DHRS7C | ENSP00000461433 | ENSP00000327975 | Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | 0.606 |
MCRIP1 | DNAH8 | ENSP00000461433 | ENSP00000333363 | Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. | Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | 0.472 |
MCRIP1 | SAYSD1 | ENSP00000461433 | ENSP00000229903 | Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. | SAYSVFN motif domain containing 1. | 0.616 |
PLGLB2 | DHRS7C | ENSP00000352458 | ENSP00000327975 | Plasminogen like B2. | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. | 0.497 |