STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRBA2Krab-a domain-containing protein 2; KRAB-A domain containing 2 (492 aa)    
Predicted Functional Partners:
GIN1
Gypsy retrotransposon integrase-like protein 1; Gypsy retrotransposon integrase 1
      
 0.609
ZCCHC18
Zinc finger cchc domain-containing protein 18; Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family
      
 0.601
NYNRIN
Protein NYNRIN; NYN domain and retroviral integrase containing
      
 0.600
ZNF665
Zinc finger protein 665; May be involved in transcriptional regulation; Zinc fingers C2H2-type
   
 
 0.573
SGK494
Uncharacterized serine/threonine-protein kinase SgK494; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
   
  
 0.527
DENND4B
DENN domain-containing protein 4B; Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing
      
 0.520
ASPRV1
Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes
      
 0.503
SYDE2
Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; C2 domain containing
      
 0.503
ACOXL
Acyl-coenzyme A oxidase-like protein; acyl-CoA oxidase like; Belongs to the acyl-CoA oxidase family
   
  
 0.477
N4BP2
NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination
      
 0.465
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (16%) [HD]