node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC9B | FAM86B1 | ENSP00000453969 | ENSP00000407067 | Coiled-coil domain containing 9B. | Putative protein N-methyltransferase FAM86B1; Family with sequence similarity 86 member B1. | 0.507 |
CCDC9B | KRBA2 | ENSP00000453969 | ENSP00000494883 | Coiled-coil domain containing 9B. | KRAB-A domain containing 2. | 0.456 |
DIRC1 | KRBA2 | ENSP00000307860 | ENSP00000494883 | Disrupted in renal carcinoma 1. | KRAB-A domain containing 2. | 0.479 |
FAM86B1 | CCDC9B | ENSP00000407067 | ENSP00000453969 | Putative protein N-methyltransferase FAM86B1; Family with sequence similarity 86 member B1. | Coiled-coil domain containing 9B. | 0.507 |
FAM86B1 | KRBA2 | ENSP00000407067 | ENSP00000494883 | Putative protein N-methyltransferase FAM86B1; Family with sequence similarity 86 member B1. | KRAB-A domain containing 2. | 0.511 |
FANCM | GIN1 | ENSP00000267430 | ENSP00000381970 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Gypsy retrotransposon integrase 1. | 0.554 |
FANCM | KRBA2 | ENSP00000267430 | ENSP00000494883 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | KRAB-A domain containing 2. | 0.532 |
FANCM | NYNRIN | ENSP00000267430 | ENSP00000371994 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Protein NYNRIN; NYN domain and retroviral integrase containing. | 0.532 |
FANCM | ZCCHC12 | ENSP00000267430 | ENSP00000308921 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression (By similarity). | 0.532 |
FANCM | ZCCHC18 | ENSP00000267430 | ENSP00000482195 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family. | 0.532 |
GIN1 | FANCM | ENSP00000381970 | ENSP00000267430 | Gypsy retrotransposon integrase 1. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.554 |
GIN1 | KRBA2 | ENSP00000381970 | ENSP00000494883 | Gypsy retrotransposon integrase 1. | KRAB-A domain containing 2. | 0.666 |
KRBA2 | CCDC9B | ENSP00000494883 | ENSP00000453969 | KRAB-A domain containing 2. | Coiled-coil domain containing 9B. | 0.456 |
KRBA2 | DIRC1 | ENSP00000494883 | ENSP00000307860 | KRAB-A domain containing 2. | Disrupted in renal carcinoma 1. | 0.479 |
KRBA2 | FAM86B1 | ENSP00000494883 | ENSP00000407067 | KRAB-A domain containing 2. | Putative protein N-methyltransferase FAM86B1; Family with sequence similarity 86 member B1. | 0.511 |
KRBA2 | FANCM | ENSP00000494883 | ENSP00000267430 | KRAB-A domain containing 2. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |
KRBA2 | GIN1 | ENSP00000494883 | ENSP00000381970 | KRAB-A domain containing 2. | Gypsy retrotransposon integrase 1. | 0.666 |
KRBA2 | MAP3K19 | ENSP00000494883 | ENSP00000376647 | KRAB-A domain containing 2. | Mitogen-activated protein kinase kinase kinase 19. | 0.515 |
KRBA2 | NYNRIN | ENSP00000494883 | ENSP00000371994 | KRAB-A domain containing 2. | Protein NYNRIN; NYN domain and retroviral integrase containing. | 0.626 |
KRBA2 | ZCCHC12 | ENSP00000494883 | ENSP00000308921 | KRAB-A domain containing 2. | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression (By similarity). | 0.527 |