SPEM2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C17orf50	C17orf98	ENSP00000475146	ENSP00000479396	Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	0.684
C17orf50	CFAP97D1	ENSP00000475146	ENSP00000415662	Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	0.622
C17orf50	SPEM2	ENSP00000475146	ENSP00000328061	Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.	Uncharacterized protein SPEM2; SPEM family member 2.	0.609
C17orf98	C17orf50	ENSP00000479396	ENSP00000475146	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.	0.684
C17orf98	CFAP97D1	ENSP00000479396	ENSP00000415662	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	0.815
C17orf98	SPAG8	ENSP00000479396	ENSP00000340982	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.632
C17orf98	SPEM2	ENSP00000479396	ENSP00000328061	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	Uncharacterized protein SPEM2; SPEM family member 2.	0.566
CFAP97D1	C17orf50	ENSP00000415662	ENSP00000475146	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.	0.622
CFAP97D1	C17orf98	ENSP00000415662	ENSP00000479396	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	0.815
CFAP97D1	SPAG8	ENSP00000415662	ENSP00000340982	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	0.746
CFAP97D1	SPEM2	ENSP00000415662	ENSP00000328061	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	Uncharacterized protein SPEM2; SPEM family member 2.	0.536
LEXM	SPEM2	ENSP00000360320	ENSP00000328061	Lymphocyte expansion molecule.	Uncharacterized protein SPEM2; SPEM family member 2.	0.544
LEXM	TLDC2	ENSP00000360320	ENSP00000217320	Lymphocyte expansion molecule.	TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family.	0.523
SPAG8	C17orf98	ENSP00000340982	ENSP00000479396	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	0.632
SPAG8	CFAP97D1	ENSP00000340982	ENSP00000415662	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.	0.746
SPAG8	SPEM2	ENSP00000340982	ENSP00000328061	Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.	Uncharacterized protein SPEM2; SPEM family member 2.	0.569
SPEM1	SPEM2	ENSP00000315554	ENSP00000328061	Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.	Uncharacterized protein SPEM2; SPEM family member 2.	0.492
SPEM1	TMEM95	ENSP00000315554	ENSP00000374632	Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.	Transmembrane protein 95.	0.571
SPEM2	C17orf50	ENSP00000328061	ENSP00000475146	Uncharacterized protein SPEM2; SPEM family member 2.	Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.	0.609
SPEM2	C17orf98	ENSP00000328061	ENSP00000479396	Uncharacterized protein SPEM2; SPEM family member 2.	Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.	0.566