node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GLI1 | KRT79 | ENSP00000228682 | ENSP00000328358 | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. | Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family. | 0.588 |
GLI1 | LRIG1 | ENSP00000228682 | ENSP00000273261 | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. | 0.465 |
KRT2 | KRT4 | ENSP00000310861 | ENSP00000448220 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | 0.441 |
KRT2 | KRT71 | ENSP00000310861 | ENSP00000267119 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. | 0.435 |
KRT2 | KRT74 | ENSP00000310861 | ENSP00000307240 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). | 0.447 |
KRT2 | KRT77 | ENSP00000310861 | ENSP00000342710 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratin, type II cytoskeletal 1b; Keratin 77. | 0.894 |
KRT2 | KRT79 | ENSP00000310861 | ENSP00000328358 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family. | 0.613 |
KRT27 | KRT33B | ENSP00000301656 | ENSP00000251646 | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | 0.672 |
KRT27 | KRT71 | ENSP00000301656 | ENSP00000267119 | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). | Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. | 0.869 |
KRT27 | KRT74 | ENSP00000301656 | ENSP00000307240 | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). | Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). | 0.862 |
KRT27 | KRT79 | ENSP00000301656 | ENSP00000328358 | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). | Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family. | 0.596 |
KRT33B | KRT27 | ENSP00000251646 | ENSP00000301656 | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). | 0.672 |
KRT33B | KRT4 | ENSP00000251646 | ENSP00000448220 | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | 0.525 |
KRT33B | KRT71 | ENSP00000251646 | ENSP00000267119 | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. | 0.629 |
KRT33B | KRT79 | ENSP00000251646 | ENSP00000328358 | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family. | 0.551 |
KRT4 | KRT2 | ENSP00000448220 | ENSP00000310861 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). | 0.441 |
KRT4 | KRT33B | ENSP00000448220 | ENSP00000251646 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family. | 0.525 |
KRT4 | KRT71 | ENSP00000448220 | ENSP00000267119 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. | 0.422 |
KRT4 | KRT74 | ENSP00000448220 | ENSP00000307240 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). | 0.429 |
KRT4 | KRT77 | ENSP00000448220 | ENSP00000342710 | Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 1b; Keratin 77. | 0.437 |