node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMCX1 | ARMCX2 | ENSP00000361917 | ENSP00000349281 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | 0.584 |
ARMCX1 | RB1 | ENSP00000361917 | ENSP00000267163 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...] | 0.554 |
ARMCX1 | SPTAN1 | ENSP00000361917 | ENSP00000487444 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. | Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | 0.650 |
ARMCX1 | WDR49 | ENSP00000361917 | ENSP00000311343 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. | WD repeat domain 49. | 0.406 |
ARMCX2 | ARMCX1 | ENSP00000349281 | ENSP00000361917 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. | 0.584 |
ARMCX2 | ATP6V1E2 | ENSP00000349281 | ENSP00000304891 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | 0.500 |
ARMCX2 | CCDC69 | ENSP00000349281 | ENSP00000347586 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. | 0.490 |
ARMCX2 | CCDC70 | ENSP00000349281 | ENSP00000242819 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | Coiled-coil domain containing 70. | 0.513 |
ARMCX2 | DDX55 | ENSP00000349281 | ENSP00000238146 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. | 0.494 |
ARMCX2 | HABP4 | ENSP00000349281 | ENSP00000364398 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation. | 0.516 |
ARMCX2 | PSME3IP1 | ENSP00000349281 | ENSP00000335808 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | PSME3-interacting protein; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. | 0.515 |
ARMCX2 | RB1 | ENSP00000349281 | ENSP00000267163 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...] | 0.553 |
ARMCX2 | SPTAN1 | ENSP00000349281 | ENSP00000487444 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | 0.653 |
ARMCX2 | WDR49 | ENSP00000349281 | ENSP00000311343 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | WD repeat domain 49. | 0.529 |
ATP6V1E2 | ARMCX2 | ENSP00000304891 | ENSP00000349281 | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | 0.500 |
ATP6V1E2 | DDX55 | ENSP00000304891 | ENSP00000238146 | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. | 0.478 |
CCDC69 | ARMCX2 | ENSP00000347586 | ENSP00000349281 | Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | 0.490 |
CCDC70 | ARMCX2 | ENSP00000242819 | ENSP00000349281 | Coiled-coil domain containing 70. | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | 0.513 |
DDX55 | ARMCX2 | ENSP00000238146 | ENSP00000349281 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells. | 0.494 |
DDX55 | ATP6V1E2 | ENSP00000238146 | ENSP00000304891 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity). | 0.478 |