node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSAG1 | MAGEA2 | ENSP00000359310 | ENSP00000485541 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | MAGE family member A2. | 0.868 |
CSAG1 | MAGEA2B | ENSP00000359310 | ENSP00000333487 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] | 0.758 |
CSAG1 | MAGEA3 | ENSP00000359310 | ENSP00000473093 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.980 |
CSAG3 | CTAG1B | ENSP00000492276 | ENSP00000332602 | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.542 |
CSAG3 | CTAG2 | ENSP00000492276 | ENSP00000247306 | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.575 |
CSAG3 | MAGEA2 | ENSP00000492276 | ENSP00000485541 | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | MAGE family member A2. | 0.611 |
CSAG3 | MAGEA2B | ENSP00000492276 | ENSP00000333487 | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] | 0.670 |
CSAG3 | MAGEA3 | ENSP00000492276 | ENSP00000473093 | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.721 |
CTAG1B | CSAG3 | ENSP00000332602 | ENSP00000492276 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | 0.542 |
CTAG1B | CTAG2 | ENSP00000332602 | ENSP00000247306 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG1B | GAGE1 | ENSP00000332602 | ENSP00000484668 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.620 |
CTAG1B | MAGEA2 | ENSP00000332602 | ENSP00000485541 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | MAGE family member A2. | 0.828 |
CTAG1B | MAGEA2B | ENSP00000332602 | ENSP00000333487 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal d [...] | 0.819 |
CTAG1B | MAGEA3 | ENSP00000332602 | ENSP00000473093 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.974 |
CTAG1B | PMEL | ENSP00000332602 | ENSP00000402758 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. | 0.857 |
CTAG1B | TP53 | ENSP00000332602 | ENSP00000269305 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.688 |
CTAG2 | CSAG3 | ENSP00000247306 | ENSP00000492276 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype. | 0.575 |
CTAG2 | CTAG1B | ENSP00000247306 | ENSP00000332602 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG2 | GAGE1 | ENSP00000247306 | ENSP00000484668 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.686 |
CTAG2 | MAGEA2 | ENSP00000247306 | ENSP00000485541 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | MAGE family member A2. | 0.794 |