node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAP2 | CRLF3 | ENSP00000464121 | ENSP00000318804 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | 0.709 |
ADAP2 | EVI2A | ENSP00000464121 | ENSP00000247270 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. | 0.769 |
ADAP2 | EVI2B | ENSP00000464121 | ENSP00000333779 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Protein EVI2B; Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. | 0.755 |
ADAP2 | LRRC37B | ENSP00000464121 | ENSP00000340519 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B. | 0.691 |
ADAP2 | NF1 | ENSP00000464121 | ENSP00000351015 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Neurofibromin truncated; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | 0.714 |
ADAP2 | PLEK | ENSP00000464121 | ENSP00000234313 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Pleckstrin; Major protein kinase C substrate of platelets. | 0.647 |
ADAP2 | RNF135 | ENSP00000464121 | ENSP00000328340 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | E3 ubiquitin-protein ligase RNF135; E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates th [...] | 0.810 |
ADAP2 | SUZ12 | ENSP00000464121 | ENSP00000316578 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Polycomb protein SUZ12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. | 0.674 |
ADAP2 | TEFM | ENSP00000464121 | ENSP00000462963 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | Transcription elongation factor, mitochondrial; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery; Belongs to the TEFM family. | 0.646 |
ADAP2 | UTP6 | ENSP00000464121 | ENSP00000261708 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family. | 0.707 |
CRLF3 | ADAP2 | ENSP00000318804 | ENSP00000464121 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | 0.709 |
CRLF3 | EVI2A | ENSP00000318804 | ENSP00000247270 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. | 0.635 |
CRLF3 | EVI2B | ENSP00000318804 | ENSP00000333779 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Protein EVI2B; Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. | 0.639 |
CRLF3 | LRRC37B | ENSP00000318804 | ENSP00000340519 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B. | 0.725 |
CRLF3 | NF1 | ENSP00000318804 | ENSP00000351015 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Neurofibromin truncated; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. | 0.418 |
CRLF3 | RNF135 | ENSP00000318804 | ENSP00000328340 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | E3 ubiquitin-protein ligase RNF135; E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates th [...] | 0.581 |
CRLF3 | SUZ12 | ENSP00000318804 | ENSP00000316578 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Polycomb protein SUZ12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. | 0.435 |
CRLF3 | TEFM | ENSP00000318804 | ENSP00000462963 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | Transcription elongation factor, mitochondrial; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery; Belongs to the TEFM family. | 0.709 |
CRLF3 | UTP6 | ENSP00000318804 | ENSP00000261708 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression. | U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family. | 0.802 |
EVI2A | ADAP2 | ENSP00000247270 | ENSP00000464121 | Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. | 0.769 |