STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM89Transmembrane protein 89. (159 aa)    
Predicted Functional Partners:
IQCF5
IQ motif containing F5.
      
 0.712
LRRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
      
 0.667
FAM71E1
Protein FAM71E1; Family with sequence similarity 71 member E1.
      
 0.608
C4A
Complement C4-A alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
    
   0.591
FAM205A
Protein FAM205A; Family with sequence similarity 205 member A.
      
 0.583
EFCC1
EF-hand and coiled-coil domain containing 1.
      
 0.580
TCTEX1D1
Tctex1 domain containing 1.
      
 0.507
HROB
Uncharacterized protein C17orf53; Homologous recombination factor with OB-fold.
      
 0.507
LRRIQ3
Leucine rich repeats and IQ motif containing 3.
      
 0.507
C3orf18
Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18.
      
 0.480
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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