ACTL10 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTL10	AFDN	ENSP00000329647	ENSP00000355771	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions. ECO:0000250\|UniProtKB:Q9QZQ1.	0.438
ACTL10	C20orf144	ENSP00000329647	ENSP00000364370	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.493
ACTL10	FAM122C	ENSP00000329647	ENSP00000359820	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Protein FAM122C; Family with sequence similarity 122C.	0.418
ACTL10	LCP1	ENSP00000329647	ENSP00000381581	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Plastin-2; Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.	0.481
ACTL10	MYO5A	ENSP00000329647	ENSP00000382177	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Unconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.	0.418
ACTL10	NECAB3	ENSP00000329647	ENSP00000246190	Actin-like protein 10; Actin like 10; Belongs to the actin family.	N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.	0.672
ACTL10	POM121L1P	ENSP00000329647	ENSP00000481613	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Putative POM121-like protein 1.	0.405
ACTL10	SLC35E4	ENSP00000329647	ENSP00000339626	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Solute carrier family 35 member E4; Putative transporter.	0.421
ACTL10	TLN1	ENSP00000329647	ENSP00000316029	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).	0.423
ACTL10	TWF1	ENSP00000329647	ENSP00000449428	Actin-like protein 10; Actin like 10; Belongs to the actin family.	Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).	0.422
AFDN	ACTL10	ENSP00000355771	ENSP00000329647	Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions. ECO:0000250\|UniProtKB:Q9QZQ1.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.438
C20orf144	ACTL10	ENSP00000364370	ENSP00000329647	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.493
FAM122C	ACTL10	ENSP00000359820	ENSP00000329647	Protein FAM122C; Family with sequence similarity 122C.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.418
LCP1	ACTL10	ENSP00000381581	ENSP00000329647	Plastin-2; Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.481
LCP1	TLN1	ENSP00000381581	ENSP00000316029	Plastin-2; Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.	Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).	0.463
MYO5A	ACTL10	ENSP00000382177	ENSP00000329647	Unconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.418
NECAB3	ACTL10	ENSP00000246190	ENSP00000329647	N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.672
POM121L1P	ACTL10	ENSP00000481613	ENSP00000329647	Putative POM121-like protein 1.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.405
SLC35E4	ACTL10	ENSP00000339626	ENSP00000329647	Solute carrier family 35 member E4; Putative transporter.	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.421
TLN1	ACTL10	ENSP00000316029	ENSP00000329647	Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).	Actin-like protein 10; Actin like 10; Belongs to the actin family.	0.423