node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREG2 | LEMD3 | ENSP00000315203 | ENSP00000308369 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | 0.425 |
CREG2 | SFXN3 | ENSP00000315203 | ENSP00000224807 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family. | 0.454 |
CREG2 | SREK1IP1 | ENSP00000315203 | ENSP00000427401 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.518 |
CREG2 | WIPF1 | ENSP00000315203 | ENSP00000376330 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | WAS/WASL-interacting protein family member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. | 0.412 |
CREG2 | ZNF85 | ENSP00000315203 | ENSP00000329793 | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | Zinc finger protein 85; May be a transcriptional repressor. | 0.452 |
F10 | F3 | ENSP00000364709 | ENSP00000334145 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.999 |
F10 | ZNF85 | ENSP00000364709 | ENSP00000329793 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. | Zinc finger protein 85; May be a transcriptional repressor. | 0.625 |
F3 | F10 | ENSP00000334145 | ENSP00000364709 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. | 0.999 |
F3 | ZNF85 | ENSP00000334145 | ENSP00000329793 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Zinc finger protein 85; May be a transcriptional repressor. | 0.606 |
LEMD3 | CREG2 | ENSP00000308369 | ENSP00000315203 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | 0.425 |
LEMD3 | SFXN3 | ENSP00000308369 | ENSP00000224807 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family. | 0.403 |
LEMD3 | SREK1IP1 | ENSP00000308369 | ENSP00000427401 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.423 |
LEMD3 | WIPF1 | ENSP00000308369 | ENSP00000376330 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | WAS/WASL-interacting protein family member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. | 0.407 |
LEMD3 | ZNF85 | ENSP00000308369 | ENSP00000329793 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | Zinc finger protein 85; May be a transcriptional repressor. | 0.407 |
SFXN3 | CREG2 | ENSP00000224807 | ENSP00000315203 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family. | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | 0.454 |
SFXN3 | LEMD3 | ENSP00000224807 | ENSP00000308369 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family. | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | 0.403 |
SFXN3 | SREK1IP1 | ENSP00000224807 | ENSP00000427401 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.451 |
SFXN3 | ZNF85 | ENSP00000224807 | ENSP00000329793 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors ; Belongs to the sideroflexin family. | Zinc finger protein 85; May be a transcriptional repressor. | 0.455 |
SREK1IP1 | CREG2 | ENSP00000427401 | ENSP00000315203 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Protein CREG2; Cellular repressor of E1A stimulated genes 2. | 0.518 |
SREK1IP1 | LEMD3 | ENSP00000427401 | ENSP00000308369 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | 0.423 |