| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| INS | PCSK2 | ENSP00000380432 | ENSP00000262545 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily. | 0.912 |
| INS | RESP18 | ENSP00000380432 | ENSP00000330269 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.424 |
| PCSK2 | INS | ENSP00000262545 | ENSP00000380432 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.912 |
| PCSK2 | RESP18 | ENSP00000262545 | ENSP00000330269 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily. | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | 0.512 |
| RESP18 | INS | ENSP00000330269 | ENSP00000380432 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.424 |
| RESP18 | PCSK2 | ENSP00000330269 | ENSP00000262545 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily. | 0.512 |
