node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK5 | ZDHHC23 | ENSP00000418001 | ENSP00000498556 | Glycerol kinase 5. | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.463 |
LYPLA1 | ZDHHC18 | ENSP00000320043 | ENSP00000363257 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.419 |
LYPLA1 | ZDHHC23 | ENSP00000320043 | ENSP00000498556 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.466 |
LYPLA1 | ZDHHC24 | ENSP00000320043 | ENSP00000309429 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family. | 0.419 |
LYPLA1 | ZDHHC6 | ENSP00000320043 | ENSP00000358413 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Belongs to the DHHC palmitoyltransferase family. | 0.500 |
LYPLA2 | ZDHHC18 | ENSP00000363638 | ENSP00000363257 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.457 |
LYPLA2 | ZDHHC23 | ENSP00000363638 | ENSP00000498556 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.490 |
LYPLA2 | ZDHHC24 | ENSP00000363638 | ENSP00000309429 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family. | 0.530 |
LYPLA2 | ZDHHC6 | ENSP00000363638 | ENSP00000358413 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Belongs to the DHHC palmitoyltransferase family. | 0.559 |
SULT6B1 | ZDHHC23 | ENSP00000384950 | ENSP00000498556 | Sulfotransferase 6B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity). | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.500 |
ZDHHC11 | ZDHHC22 | ENSP00000283441 | ENSP00000318222 | Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family. | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity). | 0.692 |
ZDHHC11 | ZDHHC23 | ENSP00000283441 | ENSP00000498556 | Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family. | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.556 |
ZDHHC11 | ZDHHC24 | ENSP00000283441 | ENSP00000309429 | Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family. | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family. | 0.459 |
ZDHHC18 | LYPLA1 | ENSP00000363257 | ENSP00000320043 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.419 |
ZDHHC18 | LYPLA2 | ENSP00000363257 | ENSP00000363638 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity (By similarity). | 0.457 |
ZDHHC18 | ZDHHC22 | ENSP00000363257 | ENSP00000318222 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity). | 0.509 |
ZDHHC18 | ZDHHC23 | ENSP00000363257 | ENSP00000498556 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.481 |
ZDHHC22 | ZDHHC11 | ENSP00000318222 | ENSP00000283441 | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity). | Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family. | 0.692 |
ZDHHC22 | ZDHHC18 | ENSP00000318222 | ENSP00000363257 | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity). | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK. | 0.509 |
ZDHHC22 | ZDHHC23 | ENSP00000318222 | ENSP00000498556 | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By similarity). | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane. | 0.748 |