CXorf38 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRACL	CXorf38	ENSP00000356632	ENSP00000330488	Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family.	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	0.435
C9orf85	CXorf38	ENSP00000334289	ENSP00000330488	Uncharacterized protein C9orf85; Chromosome 9 open reading frame 85.	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	0.555
CXorf38	ABRACL	ENSP00000330488	ENSP00000356632	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family.	0.435
CXorf38	C9orf85	ENSP00000330488	ENSP00000334289	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Uncharacterized protein C9orf85; Chromosome 9 open reading frame 85.	0.555
CXorf38	EIF2S3	ENSP00000330488	ENSP00000253039	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]	0.520
CXorf38	ENG	ENSP00000330488	ENSP00000362299	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins [...]	0.456
CXorf38	MED14	ENSP00000330488	ENSP00000323720	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.483
CXorf38	MTMR1	ENSP00000330488	ENSP00000414178	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Myotubularin-related protein 1; Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by while find no activity with this substrate.	0.456
CXorf38	NFYC	ENSP00000330488	ENSP00000312617	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Nuclear transcription factor Y subunit gamma; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.	0.573
CXorf38	TMEM164	ENSP00000330488	ENSP00000361138	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Transmembrane protein 164; Belongs to the TMEM164 family.	0.459
CXorf38	TRIM67	ENSP00000330488	ENSP00000355613	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.509
CXorf38	ZNF182	ENSP00000330488	ENSP00000380165	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	Zinc finger protein 182; May be involved in transcriptional regulation.	0.509
EIF2S3	CXorf38	ENSP00000253039	ENSP00000330488	Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	0.520
EIF2S3	MED14	ENSP00000253039	ENSP00000323720	Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.480
EIF2S3	TRIM67	ENSP00000253039	ENSP00000355613	Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.457
ENG	CXorf38	ENSP00000362299	ENSP00000330488	Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins [...]	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	0.456
MED14	CXorf38	ENSP00000323720	ENSP00000330488	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	0.483
MED14	EIF2S3	ENSP00000323720	ENSP00000253039	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]	0.480
MED14	TRIM67	ENSP00000323720	ENSP00000355613	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Tripartite motif containing 67; Belongs to the TRIM/RBCC family.	0.457
MTMR1	CXorf38	ENSP00000414178	ENSP00000330488	Myotubularin-related protein 1; Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by while find no activity with this substrate.	Uncharacterized protein CXorf38; Chromosome X open reading frame 38.	0.456