node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRACL | CXorf38 | ENSP00000356632 | ENSP00000330488 | Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family. | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | 0.448 |
ANAPC4 | CXorf38 | ENSP00000426654 | ENSP00000330488 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | 0.523 |
CXorf38 | ABRACL | ENSP00000330488 | ENSP00000356632 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family. | 0.448 |
CXorf38 | ANAPC4 | ENSP00000330488 | ENSP00000426654 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. | 0.523 |
CXorf38 | EIF2S3 | ENSP00000330488 | ENSP00000253039 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] | 0.487 |
CXorf38 | LEO1 | ENSP00000330488 | ENSP00000299601 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | 0.490 |
CXorf38 | LIPT1 | ENSP00000330488 | ENSP00000377115 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | 0.471 |
CXorf38 | MED14 | ENSP00000330488 | ENSP00000323720 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.545 |
CXorf38 | MTMR1 | ENSP00000330488 | ENSP00000414178 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Myotubularin-related protein 1; Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown by while find no activity with this substrate. | 0.444 |
CXorf38 | TCEANC | ENSP00000330488 | ENSP00000440038 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Transcription elongation factor A N-terminal and central domain containing. | 0.531 |
CXorf38 | TMEM164 | ENSP00000330488 | ENSP00000361138 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Transmembrane protein 164; Belongs to the TMEM164 family. | 0.468 |
CXorf38 | ZNF182 | ENSP00000330488 | ENSP00000380165 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | Zinc finger protein 182; May be involved in transcriptional regulation. | 0.545 |
EIF2S3 | CXorf38 | ENSP00000253039 | ENSP00000330488 | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | 0.487 |
EIF2S3 | MED14 | ENSP00000253039 | ENSP00000323720 | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.470 |
EIF2S3 | TCEANC | ENSP00000253039 | ENSP00000440038 | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] | Transcription elongation factor A N-terminal and central domain containing. | 0.447 |
LEO1 | CXorf38 | ENSP00000299601 | ENSP00000330488 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | 0.490 |
LEO1 | TCEANC | ENSP00000299601 | ENSP00000440038 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | Transcription elongation factor A N-terminal and central domain containing. | 0.482 |
LIPT1 | CXorf38 | ENSP00000377115 | ENSP00000330488 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | 0.471 |
MED14 | CXorf38 | ENSP00000323720 | ENSP00000330488 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Uncharacterized protein CXorf38; Chromosome X open reading frame 38. | 0.545 |
MED14 | EIF2S3 | ENSP00000323720 | ENSP00000253039 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] | 0.470 |