DEXI protein (human) - STRING interaction network

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DEXI

Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family. (95 aa)

Predicted Functional Partners:

CLEC16A

0.808

RMI2

0.674

CIITA

0.593

ZC3H7A

0.588

MRPS28

0.578

RD3L

0.506

RFXAP

0.498

MAP6D1

0.491

LRRC1

0.444

KCTD2

0.442

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIITA	CLEC16A	ENSP00000485010	ENSP00000387122	MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...]	Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family.	0.681
CIITA	DEXI	ENSP00000485010	ENSP00000493467	MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...]	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	0.593
CIITA	RFXAP	ENSP00000485010	ENSP00000255476	MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...]	Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters.	0.996
CLEC16A	CIITA	ENSP00000387122	ENSP00000485010	Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family.	MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...]	0.681
CLEC16A	DEXI	ENSP00000387122	ENSP00000493467	Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family.	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	0.808
CLEC16A	RMI2	ENSP00000387122	ENSP00000310356	Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family.	RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.	0.410
DEXI	CIITA	ENSP00000493467	ENSP00000485010	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...]	0.593
DEXI	CLEC16A	ENSP00000493467	ENSP00000387122	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health; Belongs to the CLEC16A/gop-1 family.	0.808
DEXI	KCTD2	ENSP00000493467	ENSP00000312814	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2.	0.442
DEXI	LRRC1	ENSP00000493467	ENSP00000359925	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1.	0.444
DEXI	MAP6D1	ENSP00000493467	ENSP00000314560	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family.	0.491
DEXI	MRPS28	ENSP00000493467	ENSP00000276585	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Mitochondrial ribosomal protein S28; Belongs to the bacterial ribosomal protein bS1 family.	0.578
DEXI	RD3L	ENSP00000493467	ENSP00000455434	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Protein RD3-like; Retinal degeneration 3 like.	0.506
DEXI	RFXAP	ENSP00000493467	ENSP00000255476	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters.	0.498
DEXI	RMI2	ENSP00000493467	ENSP00000310356	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.	0.674
DEXI	ZC3H7A	ENSP00000493467	ENSP00000379773	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'- ATA(A/T)-5' motif in the apical loop.	0.588
KCTD2	DEXI	ENSP00000312814	ENSP00000493467	BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2.	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	0.442
LRRC1	DEXI	ENSP00000359925	ENSP00000493467	Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1.	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	0.444
MAP6D1	DEXI	ENSP00000314560	ENSP00000493467	MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family.	Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.	0.491
MAP6D1	RD3L	ENSP00000314560	ENSP00000455434	MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family.	Protein RD3-like; Retinal degeneration 3 like.	0.487