node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS7 | HHIPL1 | ENSP00000373472 | ENSP00000330601 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | 0.539 |
ADAMTS7 | JCAD | ENSP00000373472 | ENSP00000364526 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | Junctional protein associated with coronary artery disease; Junctional cadherin 5 associated. | 0.517 |
ADAMTS7 | ZC3HC1 | ENSP00000373472 | ENSP00000351052 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. | 0.507 |
CNNM2 | HHIPL1 | ENSP00000358894 | ENSP00000330601 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | 0.476 |
CNNM2 | MIA3 | ENSP00000358894 | ENSP00000340900 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | 0.529 |
CNNM2 | ZC3HC1 | ENSP00000358894 | ENSP00000351052 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. | 0.474 |
HHIPL1 | ADAMTS7 | ENSP00000330601 | ENSP00000373472 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | 0.539 |
HHIPL1 | CNNM2 | ENSP00000330601 | ENSP00000358894 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | 0.476 |
HHIPL1 | JCAD | ENSP00000330601 | ENSP00000364526 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Junctional protein associated with coronary artery disease; Junctional cadherin 5 associated. | 0.441 |
HHIPL1 | MIA3 | ENSP00000330601 | ENSP00000340900 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | 0.458 |
HHIPL1 | MRPS6 | ENSP00000330601 | ENSP00000382250 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Mitochondrial ribosomal protein S6. | 0.418 |
HHIPL1 | SMG6 | ENSP00000330601 | ENSP00000263073 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). | 0.437 |
HHIPL1 | TCF21 | ENSP00000330601 | ENSP00000356857 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types. | 0.418 |
HHIPL1 | UBE2Z | ENSP00000330601 | ENSP00000354201 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. | 0.465 |
HHIPL1 | WDR12 | ENSP00000330601 | ENSP00000261015 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.471 |
HHIPL1 | ZC3HC1 | ENSP00000330601 | ENSP00000351052 | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. | 0.507 |
JCAD | ADAMTS7 | ENSP00000364526 | ENSP00000373472 | Junctional protein associated with coronary artery disease; Junctional cadherin 5 associated. | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | 0.517 |
JCAD | HHIPL1 | ENSP00000364526 | ENSP00000330601 | Junctional protein associated with coronary artery disease; Junctional cadherin 5 associated. | HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family. | 0.441 |
JCAD | ZC3HC1 | ENSP00000364526 | ENSP00000351052 | Junctional protein associated with coronary artery disease; Junctional cadherin 5 associated. | Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. | 0.416 |
MIA3 | CNNM2 | ENSP00000340900 | ENSP00000358894 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | 0.529 |