node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL17A1 | SMIM23 | ENSP00000497653 | ENSP00000430818 | 120 kDa linear IgA disease antigen; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | Small integral membrane protein 23. | 0.577 |
CTBS | SMIM23 | ENSP00000359664 | ENSP00000430818 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family. | Small integral membrane protein 23. | 0.536 |
DCHS2 | SMIM23 | ENSP00000349768 | ENSP00000430818 | Protocadherin-23; Calcium-dependent cell-adhesion protein. | Small integral membrane protein 23. | 0.646 |
DHX35 | SMIM23 | ENSP00000252011 | ENSP00000430818 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | Small integral membrane protein 23. | 0.505 |
IQCJ-SCHIP1 | SMIM23 | ENSP00000420182 | ENSP00000430818 | IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance (By similarity). | Small integral membrane protein 23. | 0.505 |
PAX3 | PRDM16 | ENSP00000375921 | ENSP00000270722 | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family. | Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic [...] | 0.453 |
PAX3 | SMIM23 | ENSP00000375921 | ENSP00000430818 | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family. | Small integral membrane protein 23. | 0.480 |
PDE8A | SMIM23 | ENSP00000378056 | ENSP00000430818 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory- phosphorylation and stimulates RAF1-dependent EGF-activated ERK- signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. | Small integral membrane protein 23. | 0.479 |
PRDM16 | PAX3 | ENSP00000270722 | ENSP00000375921 | Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic [...] | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family. | 0.453 |
PRDM16 | SMIM23 | ENSP00000270722 | ENSP00000430818 | Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic [...] | Small integral membrane protein 23. | 0.506 |
SCHIP1 | SMIM23 | ENSP00000404860 | ENSP00000430818 | Schwannomin interacting protein 1. | Small integral membrane protein 23. | 0.506 |
SMIM23 | COL17A1 | ENSP00000430818 | ENSP00000497653 | Small integral membrane protein 23. | 120 kDa linear IgA disease antigen; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | 0.577 |
SMIM23 | CTBS | ENSP00000430818 | ENSP00000359664 | Small integral membrane protein 23. | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase; Belongs to the glycosyl hydrolase 18 family. | 0.536 |
SMIM23 | DCHS2 | ENSP00000430818 | ENSP00000349768 | Small integral membrane protein 23. | Protocadherin-23; Calcium-dependent cell-adhesion protein. | 0.646 |
SMIM23 | DHX35 | ENSP00000430818 | ENSP00000252011 | Small integral membrane protein 23. | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.505 |
SMIM23 | IQCJ-SCHIP1 | ENSP00000430818 | ENSP00000420182 | Small integral membrane protein 23. | IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance (By similarity). | 0.505 |
SMIM23 | PAX3 | ENSP00000430818 | ENSP00000375921 | Small integral membrane protein 23. | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 ; Belongs to the paired homeobox family. | 0.480 |
SMIM23 | PDE8A | ENSP00000430818 | ENSP00000378056 | Small integral membrane protein 23. | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory- phosphorylation and stimulates RAF1-dependent EGF-activated ERK- signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. | 0.479 |
SMIM23 | PRDM16 | ENSP00000430818 | ENSP00000270722 | Small integral membrane protein 23. | Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic [...] | 0.506 |
SMIM23 | SCHIP1 | ENSP00000430818 | ENSP00000404860 | Small integral membrane protein 23. | Schwannomin interacting protein 1. | 0.506 |