node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD13B | SYNDIG1L | ENSP00000378328 | ENSP00000331474 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.532 |
AREL1 | PROX2 | ENSP00000348714 | ENSP00000451223 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | 0.598 |
AREL1 | SYNDIG1L | ENSP00000348714 | ENSP00000331474 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.475 |
AREL1 | VRTN | ENSP00000348714 | ENSP00000256362 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.621 |
GSG1L2 | SYNDIG1L | ENSP00000465978 | ENSP00000331474 | Germ cell-specific gene 1-like protein 2; GSG1 like 2. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.643 |
PGGHG | SYNDIG1L | ENSP00000387185 | ENSP00000331474 | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.497 |
PROX2 | AREL1 | ENSP00000451223 | ENSP00000348714 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.598 |
PROX2 | SYNDIG1L | ENSP00000451223 | ENSP00000331474 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.541 |
PROX2 | VRTN | ENSP00000451223 | ENSP00000256362 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | Vertnin; Vertebrae development associated; Belongs to the vertnin family. | 0.726 |
PRRT1B | SYNDIG1L | ENSP00000490857 | ENSP00000331474 | Proline rich transmembrane protein 1B. | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | 0.508 |
PRRT1B | TMEM233 | ENSP00000490857 | ENSP00000403130 | Proline rich transmembrane protein 1B. | Transmembrane protein 233. | 0.547 |
SYNDIG1L | ANKRD13B | ENSP00000331474 | ENSP00000378328 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. | 0.532 |
SYNDIG1L | AREL1 | ENSP00000331474 | ENSP00000348714 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation. | 0.475 |
SYNDIG1L | GSG1L2 | ENSP00000331474 | ENSP00000465978 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Germ cell-specific gene 1-like protein 2; GSG1 like 2. | 0.643 |
SYNDIG1L | PGGHG | ENSP00000331474 | ENSP00000387185 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. | 0.497 |
SYNDIG1L | PROX2 | ENSP00000331474 | ENSP00000451223 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family. | 0.541 |
SYNDIG1L | PRRT1B | ENSP00000331474 | ENSP00000490857 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Proline rich transmembrane protein 1B. | 0.508 |
SYNDIG1L | SYT6 | ENSP00000331474 | ENSP00000477344 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Synaptotagmin-6; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). | 0.496 |
SYNDIG1L | TMEM108 | ENSP00000331474 | ENSP00000324651 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrit [...] | 0.498 |
SYNDIG1L | TMEM233 | ENSP00000331474 | ENSP00000403130 | Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like. | Transmembrane protein 233. | 0.593 |