node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADA2 | CECR2 | ENSP00000382731 | ENSP00000383428 | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI- type complex. It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. May also be inv [...] | 0.467 |
ADA2 | XKR3 | ENSP00000382731 | ENSP00000331704 | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.415 |
ARSD | XKR3 | ENSP00000370546 | ENSP00000331704 | Arylsulfatase D. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.573 |
ARSD | ZNF335 | ENSP00000370546 | ENSP00000325326 | Arylsulfatase D. | Zinc finger protein 335; Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. | 0.400 |
CCDC89 | FRG2B | ENSP00000320649 | ENSP00000401310 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Protein FRG2-like-1; FSHD region gene 2 family member B. | 0.507 |
CCDC89 | KRTAP10-1 | ENSP00000320649 | ENSP00000383226 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.507 |
CCDC89 | XKR3 | ENSP00000320649 | ENSP00000331704 | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.410 |
CCT8L2 | XKR3 | ENSP00000353048 | ENSP00000331704 | T-complex protein 1 subunit theta-like 2; Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis; Belongs to the TCP-1 chaperonin family. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.406 |
CECR2 | ADA2 | ENSP00000383428 | ENSP00000382731 | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI- type complex. It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. May also be inv [...] | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. | 0.467 |
CECR2 | XKR3 | ENSP00000383428 | ENSP00000331704 | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI- type complex. It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. May also be inv [...] | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.424 |
FRG2B | CCDC89 | ENSP00000401310 | ENSP00000320649 | Protein FRG2-like-1; FSHD region gene 2 family member B. | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.507 |
FRG2B | KRTAP10-1 | ENSP00000401310 | ENSP00000383226 | Protein FRG2-like-1; FSHD region gene 2 family member B. | Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.523 |
FRG2B | XKR3 | ENSP00000401310 | ENSP00000331704 | Protein FRG2-like-1; FSHD region gene 2 family member B. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.420 |
KEL | XKR3 | ENSP00000347409 | ENSP00000331704 | Kell blood group glycoprotein; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.889 |
KRTAP10-1 | CCDC89 | ENSP00000383226 | ENSP00000320649 | Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Coiled-coil domain containing 89; Belongs to the CCDC89 family. | 0.507 |
KRTAP10-1 | FRG2B | ENSP00000383226 | ENSP00000401310 | Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Protein FRG2-like-1; FSHD region gene 2 family member B. | 0.523 |
KRTAP10-1 | XKR3 | ENSP00000383226 | ENSP00000331704 | Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.431 |
NUP214 | XKR3 | ENSP00000352400 | ENSP00000331704 | Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. | XK-related protein 3; XK related 3; Belongs to the XK family. | 0.581 |
XKR3 | ADA2 | ENSP00000331704 | ENSP00000382731 | XK-related protein 3; XK related 3; Belongs to the XK family. | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. | 0.415 |
XKR3 | ARSD | ENSP00000331704 | ENSP00000370546 | XK-related protein 3; XK related 3; Belongs to the XK family. | Arylsulfatase D. | 0.573 |