STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRR4Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family (79 aa)    
Predicted Functional Partners:
FLG2
Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family
   
  
 0.770
TCHHL1
S100 fused type protein family; Belongs to the S-100 family
   
  
 0.739
KPRP
Keratinocyte proline rich protein
   
  
 0.737
SPRR3
Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins
   
  
 0.729
S100A2
Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing
   
  
 0.721
HRNR
Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family
   
  
 0.704
S100A7L2
S100 calcium binding protein A7 like 2; EF-hand domain containing
   
  
 0.693
S100A3
Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins
      
 0.692
LCE6A
Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum
   
  
 0.666
LELP1
Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family
      
 0.664
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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