STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRR4Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family. (79 aa)    
Predicted Functional Partners:
LCE2A
Late cornified envelope protein 2A; Precursors of the cornified envelope of the stratum corneum.
   
  
 0.703
KPRP
Keratinocyte proline rich protein.
   
  
 0.694
LOR
Loricrin; Major keratinocyte cell envelope protein.
   
  
 0.691
SPRR3
Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes.
   
  
 0.683
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family.
   
  
 0.658
LELP1
Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family.
   
  
 0.639
TCHHL1
Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family.
   
  
 0.634
LCE3E
Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum.
   
  
 0.584
LCE6A
Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum. Belongs to the LCE family.
   
  
 0.581
LCE1A
Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.
   
  
 0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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