node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL14 | ATP2B4 | ENSP00000323847 | ENSP00000350310 | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. | 0.409 |
ARL14 | FREM3 | ENSP00000323847 | ENSP00000332886 | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | 0.590 |
ARL14 | HBB | ENSP00000323847 | ENSP00000494175 | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. | 0.459 |
ATP2B4 | ARL14 | ENSP00000350310 | ENSP00000323847 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | 0.409 |
ATP2B4 | FREM3 | ENSP00000350310 | ENSP00000332886 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | 0.515 |
ATP2B4 | HBB | ENSP00000350310 | ENSP00000494175 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. | 0.560 |
ATP2B4 | USP38 | ENSP00000350310 | ENSP00000303434 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. | Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme exhibiting a preference towards 'Lys- 63'-linked ubiquitin chains; Belongs to the peptidase C19 family. | 0.412 |
FREM3 | ARL14 | ENSP00000332886 | ENSP00000323847 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. | 0.590 |
FREM3 | ATP2B4 | ENSP00000332886 | ENSP00000350310 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. | 0.515 |
FREM3 | GRIP1 | ENSP00000332886 | ENSP00000381098 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.588 |
FREM3 | GYPA | ENSP00000332886 | ENSP00000354003 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | 0.693 |
FREM3 | GYPB | ENSP00000332886 | ENSP00000427690 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Glycophorin-B; This protein is a minor sialoglycoprotein in erythrocyte membranes; Belongs to the glycophorin-A family. | 0.696 |
FREM3 | GYPE | ENSP00000332886 | ENSP00000351430 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Glycophorin-E; This protein is a minor sialoglycoprotein in human erythrocyte membranes; Belongs to the glycophorin-A family. | 0.729 |
FREM3 | HBB | ENSP00000332886 | ENSP00000494175 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. | 0.550 |
FREM3 | SMARCA5 | ENSP00000332886 | ENSP00000283131 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; Helicase that possesses intrinsic ATP-dependent nucleosome- remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. [...] | 0.558 |
FREM3 | USP38 | ENSP00000332886 | ENSP00000303434 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme exhibiting a preference towards 'Lys- 63'-linked ubiquitin chains; Belongs to the peptidase C19 family. | 0.541 |
FREM3 | UTS2B | ENSP00000332886 | ENSP00000340526 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family. | 0.503 |
GRIP1 | FREM3 | ENSP00000381098 | ENSP00000332886 | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | 0.588 |
GYPA | FREM3 | ENSP00000354003 | ENSP00000332886 | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion. | 0.693 |
GYPA | GYPB | ENSP00000354003 | ENSP00000427690 | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for [...] | Glycophorin-B; This protein is a minor sialoglycoprotein in erythrocyte membranes; Belongs to the glycophorin-A family. | 0.999 |