node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADTRP | TTC32 | ENSP00000229583 | ENSP00000333018 | Androgen-dependent TFPI-regulating protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro). Belongs to the AIG1 family. | Tetratricopeptide repeat domain 32. | 0.507 |
ATP2B1 | TTC32 | ENSP00000392043 | ENSP00000333018 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | Tetratricopeptide repeat domain 32. | 0.509 |
BTNL2 | TSBP1 | ENSP00000390613 | ENSP00000415517 | Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Testis expressed basic protein 1. | 0.698 |
BTNL2 | TTC32 | ENSP00000390613 | ENSP00000333018 | Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Tetratricopeptide repeat domain 32. | 0.508 |
CHST9 | TTC32 | ENSP00000480991 | ENSP00000333018 | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. | Tetratricopeptide repeat domain 32. | 0.530 |
GUCY1A1 | TTC32 | ENSP00000296518 | ENSP00000333018 | Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Tetratricopeptide repeat domain 32. | 0.560 |
HECTD4 | TTC32 | ENSP00000366783 | ENSP00000333018 | Probable E3 ubiquitin-protein ligase HECTD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. | Tetratricopeptide repeat domain 32. | 0.488 |
LEO1 | TTC32 | ENSP00000299601 | ENSP00000333018 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | Tetratricopeptide repeat domain 32. | 0.475 |
TSBP1 | BTNL2 | ENSP00000415517 | ENSP00000390613 | Testis expressed basic protein 1. | Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.698 |
TSBP1 | TTC32 | ENSP00000415517 | ENSP00000333018 | Testis expressed basic protein 1. | Tetratricopeptide repeat domain 32. | 0.591 |
TTC32 | ADTRP | ENSP00000333018 | ENSP00000229583 | Tetratricopeptide repeat domain 32. | Androgen-dependent TFPI-regulating protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro). Belongs to the AIG1 family. | 0.507 |
TTC32 | ATP2B1 | ENSP00000333018 | ENSP00000392043 | Tetratricopeptide repeat domain 32. | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] | 0.509 |
TTC32 | BTNL2 | ENSP00000333018 | ENSP00000390613 | Tetratricopeptide repeat domain 32. | Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.508 |
TTC32 | CHST9 | ENSP00000333018 | ENSP00000480991 | Tetratricopeptide repeat domain 32. | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. | 0.530 |
TTC32 | GUCY1A1 | ENSP00000333018 | ENSP00000296518 | Tetratricopeptide repeat domain 32. | Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.560 |
TTC32 | HECTD4 | ENSP00000333018 | ENSP00000366783 | Tetratricopeptide repeat domain 32. | Probable E3 ubiquitin-protein ligase HECTD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. | 0.488 |
TTC32 | LEO1 | ENSP00000333018 | ENSP00000299601 | Tetratricopeptide repeat domain 32. | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] | 0.475 |
TTC32 | TSBP1 | ENSP00000333018 | ENSP00000415517 | Tetratricopeptide repeat domain 32. | Testis expressed basic protein 1. | 0.591 |
TTC32 | WDR35 | ENSP00000333018 | ENSP00000314444 | Tetratricopeptide repeat domain 32. | WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis. | 0.739 |
TTC32 | ZNF18 | ENSP00000333018 | ENSP00000315664 | Tetratricopeptide repeat domain 32. | Zinc finger protein 18; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.628 |