node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP7 | C14orf180 | ENSP00000297988 | ENSP00000333041 | Aquaporin-7; Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). Belongs to the MIP/aqua [...] | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.645 |
AQP7 | PLIN1 | ENSP00000297988 | ENSP00000300055 | Aquaporin-7; Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). Belongs to the MIP/aqua [...] | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. | 0.792 |
C14orf180 | AQP7 | ENSP00000333041 | ENSP00000297988 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Aquaporin-7; Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). Belongs to the MIP/aqua [...] | 0.645 |
C14orf180 | CD300LG | ENSP00000333041 | ENSP00000321005 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity). | 0.473 |
C14orf180 | CD74 | ENSP00000333041 | ENSP00000009530 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | HLA class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. | 0.487 |
C14orf180 | OR4F15 | ENSP00000333041 | ENSP00000333184 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Olfactory receptor 4F15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.544 |
C14orf180 | OR4F4 | ENSP00000333041 | ENSP00000317482 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Olfactory receptor 4F4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.446 |
C14orf180 | OR4F6 | ENSP00000333041 | ENSP00000327525 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Olfactory receptor 4F6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.479 |
C14orf180 | PLIN1 | ENSP00000333041 | ENSP00000300055 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. | 0.447 |
C14orf180 | TRARG1 | ENSP00000333041 | ENSP00000329548 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. | 0.628 |
C14orf180 | ZNF623 | ENSP00000333041 | ENSP00000445979 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Zinc finger protein 623; May be involved in transcriptional regulation. | 0.439 |
C14orf180 | ZNF75A | ENSP00000333041 | ENSP00000459566 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | Zinc finger protein 75A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.556 |
CD300LG | C14orf180 | ENSP00000321005 | ENSP00000333041 | CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity). | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.473 |
CD74 | C14orf180 | ENSP00000009530 | ENSP00000333041 | HLA class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.487 |
OR4F15 | C14orf180 | ENSP00000333184 | ENSP00000333041 | Olfactory receptor 4F15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.544 |
OR4F4 | C14orf180 | ENSP00000317482 | ENSP00000333041 | Olfactory receptor 4F4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.446 |
OR4F6 | C14orf180 | ENSP00000327525 | ENSP00000333041 | Olfactory receptor 4F6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.479 |
PLIN1 | AQP7 | ENSP00000300055 | ENSP00000297988 | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. | Aquaporin-7; Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity). Belongs to the MIP/aqua [...] | 0.792 |
PLIN1 | C14orf180 | ENSP00000300055 | ENSP00000333041 | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180. | 0.447 |
PLIN1 | TRARG1 | ENSP00000300055 | ENSP00000329548 | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. | Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. | 0.546 |