MBD3L3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Coexpression

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[Homology]

Score

MBD3L3

methyl-CpG binding domain protein 3 like 3. (208 aa)

Predicted Functional Partners:

MBD3L2

0.868

MBD3L5

0.780

LEUTX

0.701

PRAMEF15

0.698

PRAMEF25

0.639

PRAMEF9

0.615

TRIM49

0.562

TRIM43

0.549

DUXA

0.533

H3Y1

0.517

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUXA	LEUTX	ENSP00000452398	ENSP00000380053	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	Leucine twenty homeobox.	0.746
DUXA	MBD3L2	ENSP00000452398	ENSP00000370800	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.	0.433
DUXA	MBD3L3	ENSP00000452398	ENSP00000333183	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	methyl-CpG binding domain protein 3 like 3.	0.533
DUXA	PRAMEF15	ENSP00000452398	ENSP00000365322	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	PRAME family member 15; Belongs to the PRAME family.	0.417
H3Y1	LEUTX	ENSP00000496014	ENSP00000380053	Histone H3.Y; Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access. Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA repl [...]	Leucine twenty homeobox.	0.437
H3Y1	MBD3L3	ENSP00000496014	ENSP00000333183	Histone H3.Y; Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access. Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA repl [...]	methyl-CpG binding domain protein 3 like 3.	0.517
H3Y1	TRIM43	ENSP00000496014	ENSP00000272395	Histone H3.Y; Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access. Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA repl [...]	Tripartite motif containing 43.	0.468
LEUTX	DUXA	ENSP00000380053	ENSP00000452398	Leucine twenty homeobox.	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	0.746
LEUTX	H3Y1	ENSP00000380053	ENSP00000496014	Leucine twenty homeobox.	Histone H3.Y; Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access. Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA repl [...]	0.437
LEUTX	MBD3L2	ENSP00000380053	ENSP00000370800	Leucine twenty homeobox.	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.	0.782
LEUTX	MBD3L3	ENSP00000380053	ENSP00000333183	Leucine twenty homeobox.	methyl-CpG binding domain protein 3 like 3.	0.701
LEUTX	MBD3L5	ENSP00000380053	ENSP00000331435	Leucine twenty homeobox.	methyl-CpG binding domain protein 3 like 5.	0.627
LEUTX	PRAMEF15	ENSP00000380053	ENSP00000365322	Leucine twenty homeobox.	PRAME family member 15; Belongs to the PRAME family.	0.599
LEUTX	PRAMEF25	ENSP00000380053	ENSP00000481683	Leucine twenty homeobox.	PRAME family member 25; Belongs to the PRAME family.	0.520
LEUTX	PRAMEF9	ENSP00000380053	ENSP00000485258	Leucine twenty homeobox.	PRAME family member 9.	0.485
LEUTX	TRIM43	ENSP00000380053	ENSP00000272395	Leucine twenty homeobox.	Tripartite motif containing 43.	0.746
LEUTX	TRIM49	ENSP00000380053	ENSP00000327604	Leucine twenty homeobox.	Tripartite motif containing 49; Belongs to the TRIM/RBCC family.	0.426
MBD3L2	DUXA	ENSP00000370800	ENSP00000452398	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.	Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.	0.433
MBD3L2	LEUTX	ENSP00000370800	ENSP00000380053	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.	Leucine twenty homeobox.	0.782
MBD3L2	MBD3L3	ENSP00000370800	ENSP00000333183	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.	methyl-CpG binding domain protein 3 like 3.	0.868