| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CACNA1E | SLC24A3 | ENSP00000356545 | ENSP00000333519 | Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels con [...] | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.410 |
| CFAP61 | SLC24A3 | ENSP00000245957 | ENSP00000333519 | Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.471 |
| GET3 | GET4 | ENSP00000466379 | ENSP00000265857 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] | 0.999 |
| GET3 | SLC24A3 | ENSP00000466379 | ENSP00000333519 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.438 |
| GET4 | GET3 | ENSP00000265857 | ENSP00000466379 | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.999 |
| GET4 | SLC24A3 | ENSP00000265857 | ENSP00000333519 | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.480 |
| OR8G5 | SLC24A3 | ENSP00000477014 | ENSP00000333519 | Olfactory receptor 8G5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.458 |
| RBBP9 | SLC24A3 | ENSP00000336866 | ENSP00000333519 | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.475 |
| RBBP9 | ZNF133 | ENSP00000336866 | ENSP00000439427 | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.683 |
| RIN2 | SLC24A3 | ENSP00000255006 | ENSP00000333519 | Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Belongs to the RIN (Ras interaction/interference) family. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.573 |
| SLC24A3 | CACNA1E | ENSP00000333519 | ENSP00000356545 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels con [...] | 0.410 |
| SLC24A3 | CFAP61 | ENSP00000333519 | ENSP00000245957 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes. | 0.471 |
| SLC24A3 | GET3 | ENSP00000333519 | ENSP00000466379 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.438 |
| SLC24A3 | GET4 | ENSP00000333519 | ENSP00000265857 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...] | 0.480 |
| SLC24A3 | OR8G5 | ENSP00000333519 | ENSP00000477014 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Olfactory receptor 8G5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.458 |
| SLC24A3 | RBBP9 | ENSP00000333519 | ENSP00000336866 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | 0.475 |
| SLC24A3 | RIN2 | ENSP00000333519 | ENSP00000255006 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Belongs to the RIN (Ras interaction/interference) family. | 0.573 |
| SLC24A3 | ZNF133 | ENSP00000333519 | ENSP00000439427 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.501 |
| ZNF133 | RBBP9 | ENSP00000439427 | ENSP00000336866 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | 0.683 |
| ZNF133 | SLC24A3 | ENSP00000439427 | ENSP00000333519 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.501 |
