TCFL5 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TCFL5

Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis. (500 aa)

Predicted Functional Partners:

PPFIBP2

0.574

RBM28

0.508

ALB

0.487

MORN3

0.450

CHGA

0.416

ZFX

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CHGA	ENSP00000295897	ENSP00000216492	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...]	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.	0.433
ALB	TCFL5	ENSP00000295897	ENSP00000334294	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...]	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	0.487
CHGA	ALB	ENSP00000216492	ENSP00000295897	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...]	0.433
CHGA	TCFL5	ENSP00000216492	ENSP00000334294	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	0.416
MORN3	TCFL5	ENSP00000347486	ENSP00000334294	MORN repeat containing 3.	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	0.450
PPFIBP2	TCFL5	ENSP00000299492	ENSP00000334294	Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Belongs to the liprin family. Liprin-beta subfamily.	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	0.574
RBM28	TCFL5	ENSP00000223073	ENSP00000334294	RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes.	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	0.508
TCFL5	ALB	ENSP00000334294	ENSP00000295897	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific man [...]	0.487
TCFL5	CHGA	ENSP00000334294	ENSP00000216492	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.	0.416
TCFL5	MORN3	ENSP00000334294	ENSP00000347486	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	MORN repeat containing 3.	0.450
TCFL5	PPFIBP2	ENSP00000334294	ENSP00000299492	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Belongs to the liprin family. Liprin-beta subfamily.	0.574
TCFL5	RBM28	ENSP00000334294	ENSP00000223073	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes.	0.508
TCFL5	ZFX	ENSP00000334294	ENSP00000368486	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	Zinc finger X-chromosomal protein; Probable transcriptional activator.	0.403
ZFX	TCFL5	ENSP00000368486	ENSP00000334294	Zinc finger X-chromosomal protein; Probable transcriptional activator.	Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.	0.403