FAM9C protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5orf47	FAM9C	ENSP00000340887	ENSP00000334430	Uncharacterized protein C5orf47; Chromosome 5 open reading frame 47.	Protein FAM9C; Family with sequence similarity 9 member C.	0.459
C5orf47	TEX19	ENSP00000340887	ENSP00000331500	Uncharacterized protein C5orf47; Chromosome 5 open reading frame 47.	Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...]	0.421
FAM9C	C5orf47	ENSP00000334430	ENSP00000340887	Protein FAM9C; Family with sequence similarity 9 member C.	Uncharacterized protein C5orf47; Chromosome 5 open reading frame 47.	0.459
FAM9C	MAJIN	ENSP00000334430	ENSP00000301896	Protein FAM9C; Family with sequence similarity 9 member C.	Membrane anchored junction protein.	0.454
FAM9C	MEIOB	ENSP00000334430	ENSP00000314484	Protein FAM9C; Family with sequence similarity 9 member C.	Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...]	0.525
FAM9C	MEIOC	ENSP00000334430	ENSP00000386452	Protein FAM9C; Family with sequence similarity 9 member C.	Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.	0.507
FAM9C	OGFOD1	ENSP00000334430	ENSP00000457258	Protein FAM9C; Family with sequence similarity 9 member C.	Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family.	0.657
FAM9C	REC114	ENSP00000334430	ENSP00000328423	Protein FAM9C; Family with sequence similarity 9 member C.	Meiotic recombination protein REC114; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis; Belongs to the REC114 family.	0.480
FAM9C	SPHAR	ENSP00000334430	ENSP00000355649	Protein FAM9C; Family with sequence similarity 9 member C.	Protein SPHAR.	0.500
FAM9C	SYCE1	ENSP00000334430	ENSP00000303978	Protein FAM9C; Family with sequence similarity 9 member C.	Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.	0.503
FAM9C	SYCE1L	ENSP00000334430	ENSP00000367911	Protein FAM9C; Family with sequence similarity 9 member C.	Synaptonemal complex central element protein 1-like; May be involved in meiosis.	0.532
FAM9C	TEX19	ENSP00000334430	ENSP00000331500	Protein FAM9C; Family with sequence similarity 9 member C.	Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...]	0.495
MAJIN	FAM9C	ENSP00000301896	ENSP00000334430	Membrane anchored junction protein.	Protein FAM9C; Family with sequence similarity 9 member C.	0.454
MAJIN	MEIOB	ENSP00000301896	ENSP00000314484	Membrane anchored junction protein.	Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...]	0.476
MAJIN	MEIOC	ENSP00000301896	ENSP00000386452	Membrane anchored junction protein.	Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.	0.556
MAJIN	REC114	ENSP00000301896	ENSP00000328423	Membrane anchored junction protein.	Meiotic recombination protein REC114; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis; Belongs to the REC114 family.	0.493
MAJIN	SYCE1	ENSP00000301896	ENSP00000303978	Membrane anchored junction protein.	Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.	0.596
MAJIN	SYCE1L	ENSP00000301896	ENSP00000367911	Membrane anchored junction protein.	Synaptonemal complex central element protein 1-like; May be involved in meiosis.	0.569
MAJIN	TEX19	ENSP00000301896	ENSP00000331500	Membrane anchored junction protein.	Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elemen [...]	0.468
MEIOB	FAM9C	ENSP00000314484	ENSP00000334430	Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...]	Protein FAM9C; Family with sequence similarity 9 member C.	0.525