node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT7 | DHRS4L2 | ENSP00000367086 | ENSP00000334801 | Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain. | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | 0.515 |
ANKRD20A2 | ANKRD20A4 | ENSP00000366826 | ENSP00000349891 | Ankyrin repeat domain-containing protein 20A2. | Ankyrin repeat domain-containing protein 20A4. | 0.631 |
ANKRD20A2 | DHRS4L2 | ENSP00000366826 | ENSP00000334801 | Ankyrin repeat domain-containing protein 20A2. | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | 0.516 |
ANKRD20A2 | FAM72B | ENSP00000366826 | ENSP00000358397 | Ankyrin repeat domain-containing protein 20A2. | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | 0.447 |
ANKRD20A4 | ANKRD20A2 | ENSP00000349891 | ENSP00000366826 | Ankyrin repeat domain-containing protein 20A4. | Ankyrin repeat domain-containing protein 20A2. | 0.631 |
ANKRD20A4 | DHRS4L2 | ENSP00000349891 | ENSP00000334801 | Ankyrin repeat domain-containing protein 20A4. | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | 0.516 |
ANKRD20A4 | FAM72B | ENSP00000349891 | ENSP00000358397 | Ankyrin repeat domain-containing protein 20A4. | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | 0.447 |
D2HGDH | DHRS4L2 | ENSP00000315351 | ENSP00000334801 | D-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha- ketoglutarate. | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | 0.500 |
DHRS4 | DHRS4L2 | ENSP00000326219 | ENSP00000334801 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | 0.717 |
DHRS4 | FASN | ENSP00000326219 | ENSP00000304592 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.505 |
DHRS4 | FDX1 | ENSP00000326219 | ENSP00000260270 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | 0.533 |
DHRS4 | GTF2H2C | ENSP00000326219 | ENSP00000422907 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | General transcription factor IIH subunit 2-like protein; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. | 0.418 |
DHRS4L2 | ACOT7 | ENSP00000334801 | ENSP00000367086 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain. | 0.515 |
DHRS4L2 | ANKRD20A2 | ENSP00000334801 | ENSP00000366826 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | Ankyrin repeat domain-containing protein 20A2. | 0.516 |
DHRS4L2 | ANKRD20A4 | ENSP00000334801 | ENSP00000349891 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | Ankyrin repeat domain-containing protein 20A4. | 0.516 |
DHRS4L2 | D2HGDH | ENSP00000334801 | ENSP00000315351 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | D-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha- ketoglutarate. | 0.500 |
DHRS4L2 | DHRS4 | ENSP00000334801 | ENSP00000326219 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.717 |
DHRS4L2 | FAM72B | ENSP00000334801 | ENSP00000358397 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | 0.485 |
DHRS4L2 | FASN | ENSP00000334801 | ENSP00000304592 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.496 |
DHRS4L2 | FDX1 | ENSP00000334801 | ENSP00000260270 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. | Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity). Belongs to the adrenodoxin/putidaredoxin family. | 0.472 |