node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCL3 | SOWAHB | ENSP00000435770 | ENSP00000334879 | Achaete-scute homolog 3; Transcriptional repressor. Inhibits myogenesis (By similarity). | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.441 |
C1orf210 | SOWAHB | ENSP00000430918 | ENSP00000334879 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.454 |
CCNE1 | CDC6 | ENSP00000262643 | ENSP00000209728 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | 0.902 |
CCNE1 | CDK17 | ENSP00000262643 | ENSP00000261211 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.411 |
CCNE1 | CDK18 | ENSP00000262643 | ENSP00000423665 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.485 |
CCNE1 | CDK4 | ENSP00000262643 | ENSP00000257904 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] | 0.999 |
CCNE1 | SOWAHB | ENSP00000262643 | ENSP00000334879 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.440 |
CDC6 | CCNE1 | ENSP00000209728 | ENSP00000262643 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | 0.902 |
CDC6 | CDK17 | ENSP00000209728 | ENSP00000261211 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.604 |
CDC6 | CDK18 | ENSP00000209728 | ENSP00000423665 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.633 |
CDC6 | CDK4 | ENSP00000209728 | ENSP00000257904 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] | 0.836 |
CDC6 | SOWAHB | ENSP00000209728 | ENSP00000334879 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.465 |
CDK17 | CCNE1 | ENSP00000261211 | ENSP00000262643 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | 0.411 |
CDK17 | CDC6 | ENSP00000261211 | ENSP00000209728 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | 0.604 |
CDK17 | CDK18 | ENSP00000261211 | ENSP00000423665 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.611 |
CDK17 | SOWAHB | ENSP00000261211 | ENSP00000334879 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.440 |
CDK18 | CCNE1 | ENSP00000423665 | ENSP00000262643 | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | 0.485 |
CDK18 | CDC6 | ENSP00000423665 | ENSP00000209728 | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | 0.633 |
CDK18 | CDK17 | ENSP00000423665 | ENSP00000261211 | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.611 |
CDK18 | SOWAHB | ENSP00000423665 | ENSP00000334879 | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.459 |