SOWAHB protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf210	SOWAHB	ENSP00000430918	ENSP00000334879	Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane.	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.651
C1orf210	WDR72	ENSP00000430918	ENSP00000379619	Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane.	WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.	0.530
CCNE1	CCNE2	ENSP00000262643	ENSP00000429089	G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.	G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.	0.989
CCNE1	CDC6	ENSP00000262643	ENSP00000209728	G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.	Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	0.911
CCNE1	SOWAHB	ENSP00000262643	ENSP00000334879	G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.445
CCNE2	CCNE1	ENSP00000429089	ENSP00000262643	G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.	G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.	0.989
CCNE2	CDC6	ENSP00000429089	ENSP00000209728	G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.	Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	0.881
CCNE2	SOWAHB	ENSP00000429089	ENSP00000334879	G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.445
CDC6	CCNE1	ENSP00000209728	ENSP00000262643	Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.	0.911
CDC6	CCNE2	ENSP00000209728	ENSP00000429089	Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.	0.881
CDC6	SOWAHB	ENSP00000209728	ENSP00000334879	Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.414
CDKL2	SOWAHB	ENSP00000306340	ENSP00000334879	Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2.	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.407
DIAPH1	SOWAHB	ENSP00000373706	ENSP00000334879	Protein diaphanous homolog 1; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules [...]	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.865
GPC3	SOWAHB	ENSP00000377836	ENSP00000334879	Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligand [...]	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	0.456
SOWAHB	C1orf210	ENSP00000334879	ENSP00000430918	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane.	0.651
SOWAHB	CCNE1	ENSP00000334879	ENSP00000262643	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.	0.445
SOWAHB	CCNE2	ENSP00000334879	ENSP00000429089	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.	0.445
SOWAHB	CDC6	ENSP00000334879	ENSP00000209728	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.	0.414
SOWAHB	CDKL2	ENSP00000334879	ENSP00000306340	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2.	0.407
SOWAHB	DIAPH1	ENSP00000334879	ENSP00000373706	Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.	Protein diaphanous homolog 1; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules [...]	0.865