node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACRV1 | GGN | ENSP00000432816 | ENSP00000334940 | Acrosomal vesicle protein 1. | Gametogenetin; May be involved in spermatogenesis. | 0.427 |
ACRV1 | GGNBP2 | ENSP00000432816 | ENSP00000478220 | Acrosomal vesicle protein 1. | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | 0.410 |
CNGA3 | GGN | ENSP00000272602 | ENSP00000334940 | Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evok [...] | Gametogenetin; May be involved in spermatogenesis. | 0.457 |
FANCL | GGN | ENSP00000385021 | ENSP00000334940 | E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. | Gametogenetin; May be involved in spermatogenesis. | 0.850 |
GGN | ACRV1 | ENSP00000334940 | ENSP00000432816 | Gametogenetin; May be involved in spermatogenesis. | Acrosomal vesicle protein 1. | 0.427 |
GGN | CNGA3 | ENSP00000334940 | ENSP00000272602 | Gametogenetin; May be involved in spermatogenesis. | Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evok [...] | 0.457 |
GGN | FANCL | ENSP00000334940 | ENSP00000385021 | Gametogenetin; May be involved in spermatogenesis. | E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. | 0.850 |
GGN | GGNBP2 | ENSP00000334940 | ENSP00000478220 | Gametogenetin; May be involved in spermatogenesis. | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | 0.667 |
GGN | IRX3 | ENSP00000334940 | ENSP00000331608 | Gametogenetin; May be involved in spermatogenesis. | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | 0.451 |
GGN | MAX | ENSP00000334940 | ENSP00000351490 | Gametogenetin; May be involved in spermatogenesis. | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. | 0.430 |
GGN | OAZ3 | ENSP00000334940 | ENSP00000383784 | Gametogenetin; May be involved in spermatogenesis. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER- Golgi intermediate compartment (ERGIC) to the cytos [...] | 0.558 |
GGN | PDCD2L | ENSP00000334940 | ENSP00000246535 | Gametogenetin; May be involved in spermatogenesis. | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. | 0.666 |
GGN | RTCA | ENSP00000334940 | ENSP00000260563 | Gametogenetin; May be involved in spermatogenesis. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. | 0.439 |
GGN | SPATA16 | ENSP00000334940 | ENSP00000341765 | Gametogenetin; May be involved in spermatogenesis. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.442 |
GGNBP2 | ACRV1 | ENSP00000478220 | ENSP00000432816 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Acrosomal vesicle protein 1. | 0.410 |
GGNBP2 | GGN | ENSP00000478220 | ENSP00000334940 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Gametogenetin; May be involved in spermatogenesis. | 0.667 |
GGNBP2 | OAZ3 | ENSP00000478220 | ENSP00000383784 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER- Golgi intermediate compartment (ERGIC) to the cytos [...] | 0.778 |
GGNBP2 | SPATA16 | ENSP00000478220 | ENSP00000341765 | Gametogenetin-binding protein 2; May be involved in spermatogenesis. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.412 |
IRX3 | GGN | ENSP00000331608 | ENSP00000334940 | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | Gametogenetin; May be involved in spermatogenesis. | 0.451 |
MAX | GGN | ENSP00000351490 | ENSP00000334940 | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. | Gametogenetin; May be involved in spermatogenesis. | 0.430 |