VSTM2B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BEND4	CCDC181	ENSP00000421169	ENSP00000356780	BEN domain containing 4.	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	0.439
BEND4	OR6S1	ENSP00000421169	ENSP00000313110	BEN domain containing 4.	Olfactory receptor 6S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.547
BEND4	VSTM2B	ENSP00000421169	ENSP00000335038	BEN domain containing 4.	V-set and transmembrane domain containing 2B.	0.470
BEND4	ZNF439	ENSP00000421169	ENSP00000305077	BEN domain containing 4.	Zinc finger protein 439; May be involved in transcriptional regulation.	0.509
BEND4	ZNF773	ENSP00000421169	ENSP00000282292	BEN domain containing 4.	Zinc finger protein 773; May be involved in transcriptional regulation.	0.547
BEND4	ZNF93	ENSP00000421169	ENSP00000342002	BEN domain containing 4.	Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...]	0.435
C1QL3	OR6S1	ENSP00000298943	ENSP00000313110	Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).	Olfactory receptor 6S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.471
C1QL3	VSTM2B	ENSP00000298943	ENSP00000335038	Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).	V-set and transmembrane domain containing 2B.	0.448
C1QL3	ZNF439	ENSP00000298943	ENSP00000305077	Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).	Zinc finger protein 439; May be involved in transcriptional regulation.	0.435
C1QL3	ZNF773	ENSP00000298943	ENSP00000282292	Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).	Zinc finger protein 773; May be involved in transcriptional regulation.	0.466
CCDC181	BEND4	ENSP00000356780	ENSP00000421169	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	BEN domain containing 4.	0.439
CCDC181	OR6S1	ENSP00000356780	ENSP00000313110	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	Olfactory receptor 6S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.548
CCDC181	VSTM2B	ENSP00000356780	ENSP00000335038	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	V-set and transmembrane domain containing 2B.	0.487
CCDC181	ZNF439	ENSP00000356780	ENSP00000305077	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	Zinc finger protein 439; May be involved in transcriptional regulation.	0.498
CCDC181	ZNF773	ENSP00000356780	ENSP00000282292	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	Zinc finger protein 773; May be involved in transcriptional regulation.	0.547
CCDC181	ZNF93	ENSP00000356780	ENSP00000342002	Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.	Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...]	0.435
CRTAC1	VSTM2B	ENSP00000359629	ENSP00000335038	Cartilage acidic protein 1.	V-set and transmembrane domain containing 2B.	0.492
DOC2B	VSTM2B	ENSP00000482950	ENSP00000335038	Double C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium- dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium- triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma memb [...]	V-set and transmembrane domain containing 2B.	0.496
OR6S1	BEND4	ENSP00000313110	ENSP00000421169	Olfactory receptor 6S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	BEN domain containing 4.	0.547
OR6S1	C1QL3	ENSP00000313110	ENSP00000298943	Olfactory receptor 6S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).	0.471