node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANGPTL5 | ANGPTL7 | ENSP00000335255 | ENSP00000366015 | Angiopoietin-related protein 5; Angiopoietin like 5. | Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. | 0.467 |
ANGPTL5 | ANGPTL8 | ENSP00000335255 | ENSP00000479969 | Angiopoietin-related protein 5; Angiopoietin like 5. | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). Belongs to the ANGPTL8 family. | 0.477 |
ANGPTL5 | CEP126 | ENSP00000335255 | ENSP00000263468 | Angiopoietin-related protein 5; Angiopoietin like 5. | Centrosomal protein of 126 kDa; Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation. | 0.559 |
ANGPTL5 | FAM180A | ENSP00000335255 | ENSP00000342336 | Angiopoietin-related protein 5; Angiopoietin like 5. | Protein FAM180A; Family with sequence similarity 180 member A. | 0.419 |
ANGPTL5 | FGF1 | ENSP00000335255 | ENSP00000480791 | Angiopoietin-related protein 5; Angiopoietin like 5. | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.555 |
ANGPTL5 | HLA-DRA | ENSP00000335255 | ENSP00000378786 | Angiopoietin-related protein 5; Angiopoietin like 5. | HLA class II histocompatibility antigen, DR alpha chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for pre [...] | 0.421 |
ANGPTL5 | IGFBP2 | ENSP00000335255 | ENSP00000233809 | Angiopoietin-related protein 5; Angiopoietin like 5. | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates. IGF- binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. | 0.420 |
ANGPTL5 | LILRB2 | ENSP00000335255 | ENSP00000375629 | Angiopoietin-related protein 5; Angiopoietin like 5. | Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FC [...] | 0.829 |
ANGPTL5 | THBS2 | ENSP00000335255 | ENSP00000355751 | Angiopoietin-related protein 5; Angiopoietin like 5. | Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties. | 0.407 |
ANGPTL5 | TIE1 | ENSP00000335255 | ENSP00000361554 | Angiopoietin-related protein 5; Angiopoietin like 5. | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. | 0.444 |
ANGPTL7 | ANGPTL5 | ENSP00000366015 | ENSP00000335255 | Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. | Angiopoietin-related protein 5; Angiopoietin like 5. | 0.467 |
ANGPTL7 | ANGPTL8 | ENSP00000366015 | ENSP00000479969 | Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). Belongs to the ANGPTL8 family. | 0.435 |
ANGPTL7 | TIE1 | ENSP00000366015 | ENSP00000361554 | Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. | 0.479 |
ANGPTL8 | ANGPTL5 | ENSP00000479969 | ENSP00000335255 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). Belongs to the ANGPTL8 family. | Angiopoietin-related protein 5; Angiopoietin like 5. | 0.477 |
ANGPTL8 | ANGPTL7 | ENSP00000479969 | ENSP00000366015 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity). Belongs to the ANGPTL8 family. | Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. | 0.435 |
CEP126 | ANGPTL5 | ENSP00000263468 | ENSP00000335255 | Centrosomal protein of 126 kDa; Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation. | Angiopoietin-related protein 5; Angiopoietin like 5. | 0.559 |
FAM180A | ANGPTL5 | ENSP00000342336 | ENSP00000335255 | Protein FAM180A; Family with sequence similarity 180 member A. | Angiopoietin-related protein 5; Angiopoietin like 5. | 0.419 |
FGF1 | ANGPTL5 | ENSP00000480791 | ENSP00000335255 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Angiopoietin-related protein 5; Angiopoietin like 5. | 0.555 |
FGF1 | IGFBP2 | ENSP00000480791 | ENSP00000233809 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates. IGF- binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. | 0.571 |
FGF1 | TIE1 | ENSP00000480791 | ENSP00000361554 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. | 0.618 |