Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DEFB106ADefensin beta 106A. (65 aa)    
Predicted Functional Partners:
DEFB107A
Beta-defensin 107; Has antibacterial activity.
   
  
 0.862
DEFB106B
Beta-defensin 106; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2. Belongs to the beta-defensin family.
   
 
0.815
DEFB105A
Beta-defensin 105; Has antibacterial activity.
   
  
 0.783
SPAG11B
Sperm associated antigen 11B.
      
 0.778
DEFB107B
Defensin beta 107B.
   
  
 0.700
DEFB108B
Beta-defensin 108B; Has antibacterial activity.
      
 0.676
DEFB104A
Beta-defensin 104; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Belongs to the beta-defensin family.
   
  
 0.673
DEFB103A
Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.
      
 0.662
DEFB113
Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
   
  
 0.594
DEFB110
Beta-defensin 110; Has antibacterial activity.
   
  
 0.572
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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