node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DEFB114 | DEFB116 | ENSP00000312702 | ENSP00000383396 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | 0.761 |
DEFB114 | DEFB119 | ENSP00000312702 | ENSP00000365492 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Defensin beta 119. | 0.648 |
DEFB114 | DEFB124 | ENSP00000312702 | ENSP00000326309 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. | 0.801 |
DEFB114 | DEFB125 | ENSP00000312702 | ENSP00000371847 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family. | 0.837 |
DEFB114 | DEFB126 | ENSP00000312702 | ENSP00000371835 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] | 0.834 |
DEFB114 | DEFB128 | ENSP00000312702 | ENSP00000335382 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | 0.806 |
DEFB114 | DEFB129 | ENSP00000312702 | ENSP00000246105 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 129; Has antibacterial activity. | 0.757 |
DEFB114 | DEFB132 | ENSP00000312702 | ENSP00000371813 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 132; Has antibacterial activity; Belongs to the beta-defensin family. | 0.647 |
DEFB114 | DEFB134 | ENSP00000312702 | ENSP00000435010 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family. | 0.830 |
DEFB114 | DEFB135 | ENSP00000312702 | ENSP00000371643 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family. | 0.823 |
DEFB116 | DEFB114 | ENSP00000383396 | ENSP00000312702 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. | 0.761 |
DEFB116 | DEFB119 | ENSP00000383396 | ENSP00000365492 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Defensin beta 119. | 0.787 |
DEFB116 | DEFB124 | ENSP00000383396 | ENSP00000326309 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family. | 0.765 |
DEFB116 | DEFB125 | ENSP00000383396 | ENSP00000371847 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family. | 0.831 |
DEFB116 | DEFB126 | ENSP00000383396 | ENSP00000371835 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other s [...] | 0.767 |
DEFB116 | DEFB128 | ENSP00000383396 | ENSP00000335382 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family. | 0.784 |
DEFB116 | DEFB129 | ENSP00000383396 | ENSP00000246105 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 129; Has antibacterial activity. | 0.789 |
DEFB116 | DEFB132 | ENSP00000383396 | ENSP00000371813 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 132; Has antibacterial activity; Belongs to the beta-defensin family. | 0.499 |
DEFB116 | DEFB134 | ENSP00000383396 | ENSP00000435010 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family. | 0.499 |
DEFB116 | DEFB135 | ENSP00000383396 | ENSP00000371643 | Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family. | Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family. | 0.517 |