node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGRRF1 | FOXD2 | ENSP00000216420 | ENSP00000335493 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.439 |
FOXC2 | FOXD2 | ENSP00000497759 | ENSP00000335493 | Forkhead box protein C2; Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.465 |
FOXD2 | CGRRF1 | ENSP00000335493 | ENSP00000216420 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines. | 0.439 |
FOXD2 | FOXC2 | ENSP00000335493 | ENSP00000497759 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Forkhead box protein C2; Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. | 0.465 |
FOXD2 | FOXD4 | ENSP00000335493 | ENSP00000371940 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Forkhead box D4. | 0.430 |
FOXD2 | FOXD4L6 | ENSP00000335493 | ENSP00000484875 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Forkhead box D4 like 6. | 0.489 |
FOXD2 | NOTO | ENSP00000335493 | ENSP00000381486 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Homeobox protein notochord; Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By [...] | 0.401 |
FOXD2 | SETDB1 | ENSP00000335493 | ENSP00000271640 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Required for HUSH- mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represse [...] | 0.500 |
FOXD2 | SETDB2 | ENSP00000335493 | ENSP00000346175 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis. | 0.476 |
FOXD2 | SIX5 | ENSP00000335493 | ENSP00000316842 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Homeobox protein SIX5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). | 0.488 |
FOXD2 | SUV39H1 | ENSP00000335493 | ENSP00000337976 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also requir [...] | 0.473 |
FOXD2 | SUV39H2 | ENSP00000335493 | ENSP00000346997 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.474 |
FOXD4 | FOXD2 | ENSP00000371940 | ENSP00000335493 | Forkhead box D4. | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.430 |
FOXD4L6 | FOXD2 | ENSP00000484875 | ENSP00000335493 | Forkhead box D4 like 6. | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.489 |
NOTO | FOXD2 | ENSP00000381486 | ENSP00000335493 | Homeobox protein notochord; Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By [...] | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.401 |
SETDB1 | FOXD2 | ENSP00000271640 | ENSP00000335493 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Required for HUSH- mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represse [...] | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.500 |
SETDB1 | SUV39H1 | ENSP00000271640 | ENSP00000337976 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Required for HUSH- mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represse [...] | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also requir [...] | 0.988 |
SETDB2 | FOXD2 | ENSP00000346175 | ENSP00000335493 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis. | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis. | 0.476 |
SETDB2 | SUV39H1 | ENSP00000346175 | ENSP00000337976 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis. | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also requir [...] | 0.590 |
SETDB2 | SUV39H2 | ENSP00000346175 | ENSP00000346997 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.603 |