node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP3B2 | FSD2 | ENSP00000440984 | ENSP00000335651 | AP-3 complex subunit beta-2; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into [...] | Fibronectin type III and SPRY domain containing 2. | 0.632 |
C15orf40 | FSD2 | ENSP00000403987 | ENSP00000335651 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Fibronectin type III and SPRY domain containing 2. | 0.450 |
ESD | FSD2 | ENSP00000367992 | ENSP00000335651 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. | Fibronectin type III and SPRY domain containing 2. | 0.688 |
FSD2 | AP3B2 | ENSP00000335651 | ENSP00000440984 | Fibronectin type III and SPRY domain containing 2. | AP-3 complex subunit beta-2; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into [...] | 0.632 |
FSD2 | C15orf40 | ENSP00000335651 | ENSP00000403987 | Fibronectin type III and SPRY domain containing 2. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.450 |
FSD2 | ESD | ENSP00000335651 | ENSP00000367992 | Fibronectin type III and SPRY domain containing 2. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. | 0.688 |
FSD2 | GSTZ1 | ENSP00000335651 | ENSP00000451976 | Fibronectin type III and SPRY domain containing 2. | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | 0.447 |
FSD2 | LRRC39 | ENSP00000335651 | ENSP00000480740 | Fibronectin type III and SPRY domain containing 2. | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. | 0.626 |
FSD2 | MTERF3 | ENSP00000335651 | ENSP00000287025 | Fibronectin type III and SPRY domain containing 2. | Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity); Belongs to the mTERF family. | 0.455 |
FSD2 | POLL | ENSP00000335651 | ENSP00000359181 | Fibronectin type III and SPRY domain containing 2. | DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Belongs to the DNA polymerase type-X family. | 0.444 |
FSD2 | RNF207 | ENSP00000335651 | ENSP00000367173 | Fibronectin type III and SPRY domain containing 2. | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | 0.503 |
FSD2 | SPATC1L | ENSP00000335651 | ENSP00000291672 | Fibronectin type III and SPRY domain containing 2. | Speriolin-like protein; Spermatogenesis and centriole associated 1 like. | 0.465 |
FSD2 | ZNF572 | ENSP00000335651 | ENSP00000319305 | Fibronectin type III and SPRY domain containing 2. | Zinc finger protein 572; May be involved in transcriptional regulation. | 0.445 |
GSTZ1 | FSD2 | ENSP00000451976 | ENSP00000335651 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. | Fibronectin type III and SPRY domain containing 2. | 0.447 |
LRRC39 | FSD2 | ENSP00000480740 | ENSP00000335651 | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. | Fibronectin type III and SPRY domain containing 2. | 0.626 |
LRRC39 | RNF207 | ENSP00000480740 | ENSP00000367173 | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | 0.417 |
MTERF3 | FSD2 | ENSP00000287025 | ENSP00000335651 | Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity); Belongs to the mTERF family. | Fibronectin type III and SPRY domain containing 2. | 0.455 |
POLL | FSD2 | ENSP00000359181 | ENSP00000335651 | DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Belongs to the DNA polymerase type-X family. | Fibronectin type III and SPRY domain containing 2. | 0.444 |
RNF207 | FSD2 | ENSP00000367173 | ENSP00000335651 | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | Fibronectin type III and SPRY domain containing 2. | 0.503 |
RNF207 | LRRC39 | ENSP00000367173 | ENSP00000480740 | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart. | 0.417 |