node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD10 | ABHD12B | ENSP00000273359 | ENSP00000336693 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | 0.568 |
ABHD10 | ABHD14A | ENSP00000273359 | ENSP00000273596 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family. | 0.509 |
ABHD10 | ABHD16A | ENSP00000273359 | ENSP00000379282 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | 0.541 |
ABHD10 | ABHD16B | ENSP00000273359 | ENSP00000358932 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family. | 0.553 |
ABHD10 | ABHD6 | ENSP00000273359 | ENSP00000295962 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] | 0.567 |
ABHD10 | ABHD8 | ENSP00000273359 | ENSP00000247706 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily. | 0.481 |
ABHD12B | ABHD10 | ENSP00000336693 | ENSP00000273359 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | 0.568 |
ABHD12B | ABHD14A | ENSP00000336693 | ENSP00000273596 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family. | 0.615 |
ABHD12B | ABHD16A | ENSP00000336693 | ENSP00000379282 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | 0.577 |
ABHD12B | ABHD16B | ENSP00000336693 | ENSP00000358932 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family. | 0.676 |
ABHD12B | ABHD6 | ENSP00000336693 | ENSP00000295962 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] | 0.578 |
ABHD12B | ABHD8 | ENSP00000336693 | ENSP00000247706 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily. | 0.548 |
ABHD12B | AP3B2 | ENSP00000336693 | ENSP00000440984 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | AP-3 complex subunit beta-2; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into [...] | 0.582 |
ABHD12B | CD58 | ENSP00000336693 | ENSP00000358501 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Lymphocyte function-associated antigen 3; Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. | 0.611 |
ABHD12B | CLEC19A | ENSP00000336693 | ENSP00000490375 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | C-type lectin domain containing 19A. | 0.577 |
ABHD12B | WHAMM | ENSP00000336693 | ENSP00000286760 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | WASP homolog-associated protein with actin, membranes and microtubules; Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of G [...] | 0.573 |
ABHD14A | ABHD10 | ENSP00000273596 | ENSP00000273359 | Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | 0.509 |
ABHD14A | ABHD12B | ENSP00000273596 | ENSP00000336693 | Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family. | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | 0.615 |
ABHD14A | ABHD16A | ENSP00000273596 | ENSP00000379282 | Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | 0.461 |
ABHD14A | ABHD16B | ENSP00000273596 | ENSP00000358932 | Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family. | Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family. | 0.620 |